Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor

Journal of the Neurological Sciences
Ningshan WangAmos D Korczyn

Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) are composed of 12 subunits (alpha2-alpha10 and beta2-beta4). alpha5 Subunits, expressed throughout the central nervous system (CNS) and the autonomic nervous system (ANS), possess unique pharmacological properties. The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking alpha5 nAChR subunits (alpha5-/-) and compared with those in wild-type (WT) control mice. The alpha5-/- mice showed significantly increased salivation and tremor responses to OXO. The hypothermia, bradycardia and defecation induced by OXO were of similar magnitudes in the two mouse strains. The enhanced OXO effects in alpha5-/- mice indicate inhibitory effects of alpha5 subunits in autonomic ganglia, and support the participation of these subunits in cholinergic transmission in autonomic ganglia.

References

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Citations

Sep 28, 2010·Autonomic Neuroscience : Basic & Clinical·Boris KandinovVivian E Drory
Oct 16, 2008·Addiction Biology·David E Evans, David J Drobes
Feb 9, 2012·The Journal of Biological Chemistry·Bhagirathi Dash, Ronald J Lukas

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