Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling.

Neuropharmacology
Roger L Papke, Jon Lindstrom

Abstract

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and autonomic neurotransmission. Pre- and peri-synaptic nAChRs in the brain modulate neurotransmission and are responsible for the addictive effects of nicotine. Subtypes of nAChRs in lymphocytes and non-synaptic locations may modulate inflammation and other cellular functions. All AChRs that function as ligand-gated ion channels are formed from five homologous subunits organized to form a central cation channel whose opening is regulated by ACh bound at extracellular subunit interfaces. nAChR subtype subunit composition can range from α7 homomers to α4β2α6β2β3 heteromers. Subtypes differ in affinities for ACh and other agonists like nicotine and in efficiencies with which their channels are opened and desensitized. Subtypes also differ in affinities for antagonists and for positive and negative allosteric modulators. Some agonists are "silent" with respect to channel opening, and AChRs may be able to signal metabotropic pathways by releasing G-proteins independent of channel opening. Electrophysiological studies that can resolve single-channel openings and molecular genetic approaches have allowed characterization of the structures of ligand bi...Continue Reading

References

Apr 1, 1978·The Journal of Physiology·E Neher, J H Steinbach
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D BertrandJ P Changeux
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J C MartinouJ P Merlie
Jan 1, 1990·Progress in Brain Research·S HeinemannJ Patrick
Mar 1, 1990·Clinical Pharmacology and Therapeutics·J E RoseC Schur
Sep 23, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D C Ogden, D Colquhoun
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J BoulterJ Patrick
Jan 1, 1988·The Journal of Physiology·D Colquhoun, D C Ogden
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P Whiting, J Lindstrom
Jun 6, 1985·Nature·A Brisson, P N Unwin
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B R LandM M Salpeter
Jul 26, 1996·The Journal of Biological Chemistry·F WangJ Lindstrom
Feb 1, 1997·Trends in Neurosciences·S Wonnacott
Mar 1, 1996·Trends in Neurosciences·M V Jones, G L Westbrook
Mar 28, 1998·The European Journal of Neuroscience·M AlkondonE X Albuquerque
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M K Ramarao, J B Cohen

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Citations

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