Nicotinic Acetylcholine Receptors Mediate the Suppressive Effect of an Injection of Diluted Bee Venom into the GV3 Acupoint on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats

Biological & Pharmaceutical Bulletin
Heera YoonSun Kwang Kim

Abstract

Oxaliplatin, a platinum-based chemotherapy drug, often induces acute neuropathic pain, especially cold allodynia, even after a single administration. Subcutaneous injection of diluted bee venom (BV) into acupoints has been used to treat various pain symptoms in traditional oriental medicine. Although we previously demonstrated the suppressive effect of BV injection on oxaliplatin-induced cold allodynia in rats, its neurochemical mechanism remained unclear. This study investigates whether and how the cholinergic system mediates the relieving effect of BV injection on cold allodynia in oxaliplatin-administered rats. The behavioral signs of cold allodynia induced by an oxaliplatin administration (6 mg/kg, intraperitoneally (i.p.)) were evaluated by a tail immersion test in cold water (4°C). BV (0.25 mg/kg, subcutaneously (s.c.)) injection into the Yaoyangguan acupoint, located between the spinous processes of the fourth and fifth lumbar vertebrae, significantly alleviated the cold allodynia. This relieving effect of BV injection on oxaliplatin-induced cold allodynia was blocked by a pretreatment with mecamylamine (a non-selective nicotinic receptor antagonist, 2 mg/kg, i.p.), but not by atropine (a non-selective muscarinic recepto...Continue Reading

References

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·J M ExtraM Marty
Jun 1, 1997·Brain Research. Brain Research Reviews·R E Coggeshall, S M Carlton
Oct 28, 1998·Journal of Physiology, Paris·M W DeckerS P Arneric
Mar 9, 1999·Life Sciences·J C Eisenach
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 7, 2002·Critical Reviews in Oncology/hematology·Bernard Desoize, Claudie Madoulet
Nov 15, 2002·Brain Research Bulletin·José L De la Calle, Carlos L Paíno
Apr 21, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Jae-Dong LeeSabina Lim
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven R AlbertsJohn H Donohue
Jun 15, 2007·Research in Veterinary Science·Chang Shik YinHyeong Gyun Koh
Jun 24, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sherry WolfCharles Loprinzi
May 19, 2011·Recent Patents on CNS Drug Discovery·Alessandro BartoliniCarla Ghelardini
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Woojin KimByung-Il Min
Aug 30, 2013·Biological & Pharmaceutical Bulletin·Seo-Yeon YoonDae-Hyun Roh
Sep 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Bong-Soo LimByung-Il Min
Oct 26, 2013·The Journal of Physiological Sciences : JPS·Hak Jin MoonSun Kwang Kim

❮ Previous
Next ❯

Citations

May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gihyun Lee, Hyunsu Bae
Jul 7, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ji Hwan LeeSun Kwang Kim
Apr 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bishoy El-AaragHesham R El-Seedi
Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh
May 2, 2018·Toxicon : Official Journal of the International Society on Toxinology·José Roberto Aparecido Dos Santos-PintoMario Sergio Palma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Bacterial Vaginosis

Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.