Nicotinic acetylcholine receptors mediate donepezil-induced oligodendrocyte differentiation

Journal of Neurochemistry
Osamu ImamuraKunio Takishima

Abstract

Oligodendrocytes are the myelin-forming cells of the central nervous system (CNS). Failure of myelin development and oligodendrocyte loss results in serious human disorders, including multiple sclerosis. Here, we show that donepezil, an acetlycholinesterase inhibitor developed for the treatment of Alzheimer's disease, can stimulate oligodendrocyte differentiation and maturation of neural stem cell-derived oligodendrocyte progenitor cells without affecting proliferation or cell viability. Transcripts for essential myelin-associated genes, such as PLP, MAG, MBP, CNPase, and MOG, in addition to transcription factors that regulate oligodendrocyte differentiation and myelination, were rapidly increased after treatment with donepezil. Furthermore, luciferase assays confirmed that both MAG and MBP promoters display increased activity upon donepezil-induced oligodendrocytes differentiation, suggesting that donepezil increases myelin gene expression mainly through enhanced transcription. We also found that the increase in the number of oligodendrocytes observed following donepezil treatment was significantly inhibited by the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine, but not by the muscarinic acetylcholine recepto...Continue Reading

References

Mar 10, 1999·Methods : a Companion to Methods in Enzymology·R C Armstrong
Jan 19, 2000·Current Medicinal Chemistry·H SugimotoY Kawakami
May 3, 2000·The EMBO Journal·T Kondo, M Raff
Jan 18, 2002·The New England Journal of Medicine·Ansi ChangBruce D Trapp
Feb 15, 2002·Brain : a Journal of Neurology·Guus Wolswijk
Oct 19, 2002·Progress in Neurobiology·Robert H Miller
May 8, 2003·The Journal of Pharmacology and Experimental Therapeutics·Yuki TakadaAkinori Akaike
Oct 18, 2003·Dementia and Geriatric Cognitive Disorders·Zakiya J Wynn, Jeffrey L Cummings
Jun 1, 1993·Trends in Cell Biology·S E PfeifferR Bansal
Jan 28, 2004·British Journal of Pharmacology·Silvia Di AngelantonioNicola B Mercuri
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mei XinQ Richard Lu
Apr 23, 2005·The Journal of Comparative Neurology·Minodora O Totoiu, Hans S Keirstead
Apr 27, 2005·Annals of Neurology·Yehuda PollakRaz Yirmiya
Dec 24, 2005·Nature Reviews. Neuroscience·William D RichardsonNigel Pringle
Apr 4, 2006·Brain Research·Kunlin JinDavid A Greenberg
Jul 25, 2006·Glia·Mireya Marin-HusstegePatrizia Casaccia-Bonnefil
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bénédicte MennArturo Alvarez-Buylla
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huiliang LiWilliam D Richardson
Jul 26, 2008·Journal of Neuroscience Research·Yuki Takada-TakatoriAkinori Akaike
Jun 12, 2009·Genes & Development·Stephen P J FancyDavid H Rowitch
Aug 29, 2009·Cell Communication and Signaling : CCS·Rodrigo R Resende, Avishek Adhikari
Jan 19, 2010·Genes & Development·Shen Yi B HowngBrian Popko
Oct 16, 2010·The Journal of Biological Chemistry·Kazuyuki TakataShun Shimohama
Apr 20, 2011·The Journal of Cell Biology·Céline CaillavaAnne Baron-Van Evercooren
Feb 22, 2012·Journal of Molecular Neuroscience : MN·Jian-xin Shen, Jerrel L Yakel
Sep 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthias KoenningBen Emery
Nov 1, 2012·Science·Steven A GoldmanMartha S Windrem
Jul 9, 2013·Current Opinion in Neurobiology·J Bradley Zuchero, Ben A Barres
May 14, 2014·The International Journal of Neuropsychopharmacology·Yuki KitaToshio Matsuda

❮ Previous
Next ❯

Citations

Feb 24, 2016·Frontiers in Cellular Neuroscience·Carla MarinelliPietro Giusti
Jan 20, 2017·Glia·R Douglas FieldsMaya Robnett
Apr 6, 2018·Annual Review of Neuroscience·Ragnhildur T Káradóttir, Chay T Kuo
Nov 30, 2019·Journal of Neurochemistry·Osamu ImamuraKunio Takishima
Jun 11, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ramón Cacabelos
Aug 17, 2018·BioMed Research International·Ankit TandonRajnish Kumar Chaturvedi
Aug 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhenhong LiuPengwen Wang
Dec 26, 2018·Frontiers in Cellular Neuroscience·Hai-Ying ShenLan Xiao
Nov 3, 2016·Journal of Neurophysiology·Christopher M Filley, R Douglas Fields

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.