PMID: 8953511Oct 1, 1996Paper

Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane

The Journal of Pharmacy and Pharmacology
H TakanagaA Tsuji

Abstract

In order to determine whether the vitamin nicotinic acid is absorbed via an anion antiporter, intestinal epithelial cell membrane transport mechanisms for nicotinic acid were characterized using isolated rabbit jejunal brush-border membrane vesicles. The uptake of nicotinic acid by the membrane vesicles showed an overshoot phenomenon in the presence of an outwardly directed bicarbonate gradient or an inwardly directed proton gradient and the uptakes were two times and six times greater, respectively, than that in the absence of any ion gradient. The bicarbonate-dependent initial uptake of nicotinic acid was increased at acidic pH, showing pH-dependent transport activity. An inhibitor of anion transport, 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid, specifically reduced bicarbonate-dependent transport of nicotinic acid. The initial uptakes of nicotinic acid via the anion antiporter and the proton cotransporter were specifically inhibited by monocarboxylic acids such as acetic acid, benzoic acid, D- and L-lactic acid, pravastatin and valproic acid, but not by di- or tricarboxylic acids, bile acids or amino acids. Nicotinic acid uptake activity was, furthermore, expressed in a Xenopus laevis oocyte system after injection of m...Continue Reading

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Citations

Feb 11, 2003·Biological & Pharmaceutical Bulletin·Shigemitsu TomeiJun Watanabe
Jan 4, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akira Tsuji
Jun 19, 2004·Journal of Drug Targeting·Takashi NozawaIkumi Tamai
Apr 30, 2003·Expert Opinion on Biological Therapy·Sridhar DuvvuriAshim K Mitra
Nov 17, 1999·Journal of Pharmaceutical Sciences·T OgiharaA Tsuji
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D Meredith, H C Christian
May 1, 2007·Experimental Physiology·David T Thwaites, Catriona M H Anderson
Aug 8, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hye-Ryoung KimHo-Chul Shin
Jun 20, 2006·International Journal of Pharmaceutics·Hsuan-Ming Yao, Win L Chiou
Jul 14, 2011·The Biochemical Journal·Hamid M Said
Jul 12, 2011·Microvascular Research·Masanori TachikawaVadivel Ganapathy
Nov 3, 2009·Drug Metabolism and Pharmacokinetics·Choo Bee Lean, Edmund Jon Deoon Lee
Mar 29, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Linlin MaJie Zheng
Feb 25, 2005·American Journal of Physiology. Cell Physiology·Svetlana M NabokinaHamid M Said
Feb 21, 2019·Antioxidants & Redox Signaling·Chaitanya A Kulkarni, Paul S Brookes
Apr 16, 2008·The Journal of Biological Chemistry·Andrew BahnGerhard Burckhardt
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Daisuke KobayashiIkumi Tamai
Oct 12, 2007·American Journal of Physiology. Cell Physiology·Hamid M SaidMoti L Kashyap
Apr 9, 2020·Frontiers in Oncology·Valentina AudritoSilvia Deaglio
Dec 4, 2001·Biochimica Et Biophysica Acta·A RajgopalR Zhao

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