PMID: 2879597Nov 1, 1986Paper

Nicotinic antagonists produce differing amounts of tetanic fade in the isolated diaphragm of the rat

British Journal of Pharmacology
A J Gibb, I G Marshall

Abstract

The effects of nicotine antagonists on single twitches, trains of four twitches and tetanic contractions of the isolated diaphragm of the rat were examined. Different drugs were found to produce different amounts of tetanic fade relative to depression of twitch tension. The order of activity from most able, to least able to produce fade was: hexamethonium greater than trimetaphan=atracurium=tubocurarine greater than pancuronium greater than erabutoxin b. The effect of erabutoxin b was distinctive for its almost complete lack of tetanic fade. 3,4-Diaminopyridine increased tetanic fade produced by tubocurarine, atracurium and hexamethonium, but not that produced by erabutoxin b. It is concluded that nicotinic antagonists act at more than one site at the neuromuscular junction. Assuming block of the postjunctional acetylcholine receptor produces tension depression, a second or third site must be involved in producing tetanic fade. The possibility that tetanic fade results from block of the ion channel associated with the postjunctional acetylcholine receptor or from the block of a prejunctional nicotinic receptor is discussed.

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Citations

Jun 8, 1989·European Journal of Pharmacology·J E BañosA Badia
Jan 25, 1990·European Journal of Pharmacology·R J BradleyW C Chau
Aug 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·K BlountI G Marshall
Jan 1, 1988·Trends in Pharmacological Sciences·W C BowmanA J Harborne
Nov 11, 1991·Neuroscience Letters·D F Wilson, R H Thomsen
Aug 31, 1992·Neuroscience Letters·D F Wilson, R H Thomsen
Mar 7, 2003·European Journal of Pharmacology·M Alexandrina TimóteoPaulo Correia-De-Sá
Jun 22, 2002·Toxicon : Official Journal of the International Society on Toxinology·S NirthananR Manjunatha Kini
Jun 1, 1988·Clinical and Experimental Pharmacology & Physiology·A J HarborneI G Marshall
Oct 1, 1994·British Journal of Pharmacology·G LeesR M Jones
Dec 1, 1995·The Journal of Pharmacy and Pharmacology·K P KerrF Mitchelson
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Related Concepts

3,4-diaminopyridine
Erabutoxin b
Aminopyridines
Metazoa
Neuromuscular Nondepolarizing Agents
Respiratory Diaphragm
Electric Stimulation Technique
Erabutoxins
Ganglionic Blockers
Inotropism

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