Nicotinic control of tuberoinfundibular dopaminergic neuron activity and prolactin secretion: diurnal rhythm and involvement of endogenous opioidergic system

Brain Research
K R Shieh, J T Pan

Abstract

The possible involvement of cholinergic and opioidergic neurons in the control of diurnal changes of tuberoinfundibular dopaminergic (TIDA) neuronal activity was reported. Adult Sprague-Dawley rats ovariectomized and treated with estrogen were used. All drugs were administered centrally through preimplanted intracerebroventricular cannula, and both TIDA neuronal activity and serum prolactin level were determined. Nicotine (10 ng/3 microl/rat) given at 10:00 h significantly inhibited TIDA neuronal activity from 5 to 30 min and stimulated serum PRL levels at 5 and 15 min. Co-administration of either mecamylamine (1 microg) or naloxone (2.5 microg) prevented both nicotine's effects. A dose-related (0.1-100 ng) effect of nicotine on TIDA neuronal activity and serum PRL level was also observed in the morning when TIDA neuronal activity is high and serum PRL level is low, but not in the afternoon when the former activity is low and the latter is high. When atropine (20 microg), naloxone (25 microg) or Nor-BNI (20 microg) was given at 14:00 h all increased the lowered TIDA neuronal activity in the afternoon. When atropine was co-administered with either naloxone or Nor-BNI, however, no additive effect was observed. Submaximal doses of...Continue Reading

References

Nov 24, 1977·Nature·L Grandison, A Guidotti

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Citations

Jan 8, 1999·Peptides·G A OlsonA J Kastin
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·R M Anthenelli, R A Maxwell
Jul 23, 2013·Journal of Human Reproductive Sciences·Ibukun P OyeyipoAdeyombo F Bolarinwa
Aug 21, 2013·Medical Hypotheses·Babak BahadoriMohammed F Moghadasian
Mar 20, 2015·North American Journal of Medical Sciences·Ibukun P OyeyipoAdeyombo F Bolarinwa
Dec 2, 2005·Addiction Biology·Ghollam-Reza Moshtaghi-KashanianShahriar Dabiri
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Shieh, J Pan

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