NIDDM: a rapid progressive disease. Results from a long-term, randomised, comparative study of insulin or sulphonylurea treatment

Diabetologia
K I BirkelandS Vaaler

Abstract

The objective of the present study was to assess the relative efficacy of insulin or glibenclamide treatment for non-insulin-dependent diabetes mellitus (NIDDM) over 42 months. We performed a randomised, controlled trial allocating patients treated with diet and oral antihyperglycaemic agents to treatment with glibenclamide or insulin to achieve HbAlc levels under 7.5%. We included 36 subjects with established NIDDM of more than 2 years' duration. Mean HbAlc levels were significantly reduced in patients allocated to insulin treatment from 9.1 +/- 1.4% before the start to 7.8 +/- 1.3% (p < 0.05) after 1 year, and did not change significantly thereafter throughout the study period. Mean HbAlc levels increased during the study in the patients allocated to glibenclamide treatment, and 11 of 18 patients had to be switched to insulin treatment due to increasing hyperglycaemia (HbAlc > 10%). Mean body weight increased in the subjects allocated to insulin by 7.2 +/- 4.1 kg during the study period. In conclusion, insulin was more effective than glibenclamide treatment in obtaining control over hyperglycaemia in these patients, and once improved, glycaemic control did not deteriorate over 42 months in the insulin-treated group. Two third...Continue Reading

Citations

Jan 10, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·K I BirkelandK F Hanssen
Apr 4, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Adrian N C LauCatherine H Y Yu
May 15, 2003·Diabetes & Metabolism·P Home
May 20, 2003·Journal of Advanced Nursing·Colin J GreavesJ W Stead
Apr 19, 2013·Diabetes, Obesity & Metabolism·M MonamiE Mannucci
Jun 26, 2001·Diabetes Care·P RaskinUNKNOWN Rosiglitazone Clinical Trials Study Group
Nov 25, 2016·Postgraduate Medicine·A Enrique Caballero
Jul 30, 2015·The Cochrane Database of Systematic Reviews·Bianca HemmingsenThomas P Almdal
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Anne-Marie AasKåre I Birkeland
Dec 13, 2006·Annals of Saudi Medicine·Slaven KokićSanda Tesanović

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