Oral (17 cases) or sublingual (9 cases) administration of nifedipine (10 mg), a new coronary dilator, induced a prompt and large pressure reduction in patients with severe primary hypertension. Pressure started to fall within 20 and 5 min after oral and sublingual administration, respectively, and reached the lowest levels in the next 10 min. Maximal mean arterial pressure reduction averaged 36 mm Hg; 120 min after the drug, mean arterial pressure was diminished by 19.5% of control. The hypotension was mediated through diminished peripheral resistance associated with rise of cardiac output and pulse rate. Nifedipine was also administered siblingually in 3 cases with hypertensive encephalopathy and acute left ventricular failure with average systemic and pulmonary arterial pressures from 307/164 and 91/55 mm Hg, respectively, which fell to 237/115 and 68/35 mm Hg 15 min after 10 mg of the drug, and were further reduced to 176/89 and to 47/19 mm Hg by an additional 10 mg.
Effects of nifedipine on cardiac function in patients with coronary artery disease evaluated with ambulatory radionuclide monitoring
Long-term effects of nifedipine on carbohydrate and lipid metabolism in hypertensive hemodialyzed patients
Acute natriuretic effect of nifedipine in hypertensive patients and normotensive controls--a proximal tubular effect?
Hemodynamic and reflex responses to acute and chronic antihypertensive therapy with the calcium entry blocker nifedipine
Calcium blockade as a therapeutic principle in arterial hypertension. Clinical aspects and experimental studies on isolated vessels from spontaneously hypertensive rats and normotensive man
The acute effects of nifedipine on calf and forefoot blood flow in patients with peripheral arterial insufficiency
Nifedipine attenuates the hypertensive response to tracheal intubation in pregnancy-induced hypertension
Blood pressure and heart rate in patients with ischaemic heart disease receiving nifedipine and propranolol
Beneficial effects of sublingual nifedipine in patients with ischemic heart disease and depressed left ventricular function
A comparative study of the pharmacodynamic effects of nimodipine and nifedipine in the isolated spontaneously beating rabbit heart
The effects of nifedipine on regional vascular resistance and blood flow in the spontaneously hypertensive rat
Invasive hemodynamic evaluation of sublingual captopril and nifedipine in patients with arterial hypertension after abdominal aortic surgery
An acute dose-response pharmacodynamic evaluation of orally administered isradipine (PN-200-110) in hypertensive patients.
Calcium channel antagonists. Part III: Use and comparative efficacy in hypertension and supraventricular arrhythmias. Minor indications
Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension
Antihypertensive effect of fractionated sublingual administration of nifedipine in moderate essential hypertension
Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine
Verapamil and nifedipine inhibition of contractions induced by potassium and noradrenaline in human mesenteric arteries and veins
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.