Nifedipine, a new antihypertensive with rapid action

Clinical Pharmacology and Therapeutics
M GuazziP Moruzzi

Abstract

Oral (17 cases) or sublingual (9 cases) administration of nifedipine (10 mg), a new coronary dilator, induced a prompt and large pressure reduction in patients with severe primary hypertension. Pressure started to fall within 20 and 5 min after oral and sublingual administration, respectively, and reached the lowest levels in the next 10 min. Maximal mean arterial pressure reduction averaged 36 mm Hg; 120 min after the drug, mean arterial pressure was diminished by 19.5% of control. The hypotension was mediated through diminished peripheral resistance associated with rise of cardiac output and pulse rate. Nifedipine was also administered siblingually in 3 cases with hypertensive encephalopathy and acute left ventricular failure with average systemic and pulmonary arterial pressures from 307/164 and 91/55 mm Hg, respectively, which fell to 237/115 and 68/35 mm Hg 15 min after 10 mg of the drug, and were further reduced to 176/89 and to 47/19 mm Hg by an additional 10 mg.

Citations

Oct 1, 1978·Acta Pharmacologica Et Toxicologica·E MikkelsenO L Pedersen
Dec 18, 1978·European Journal of Clinical Pharmacology·O L Pedersen, E Mikkelsen
Nov 1, 1990·Journal of Clinical Pharmacology·P K ZachariahA G Moore
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·K Landmark
Jan 1, 1989·Fundamental & Clinical Pharmacology·F Huguet
May 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B InduH Singh
Jan 1, 1988·Intensive Care Medicine·J Lopez-HerceF Ruza
Jun 1, 1987·Drug Intelligence & Clinical Pharmacy·E A Bakken
Jan 1, 1987·European Journal of Clinical Pharmacology·L R KrusellO Lederballe Pedersen
Jan 1, 1983·British Medical Journal·O BertelU C Dubach
Jun 20, 1981·British Medical Journal
Oct 1, 1993·Angiology·M A JohnsonC D Lyons
Apr 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N KumarS Gopalan
Jan 1, 1986·British Journal of Clinical Pharmacology·B N Prichard, C W Owens
Mar 1, 1985·British Heart Journal·I Malcić, D Richter
Dec 1, 1987·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·L A Cockhill, R A Remick
Jul 1, 1988·Clinical Cardiology·S G ChrysantA Hitchcock
May 1, 1989·Angiology·G KouvarasD Cokkinos
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·R KrebsR Ziegler
Jan 1, 1985·British Journal of Clinical Pharmacology·R M McCredieD A McGill
Mar 1, 1986·Drug Intelligence & Clinical Pharmacy·Y W LamJ B Warren
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·B V Reed, R F Tuma
Jan 1, 1991·European Journal of Clinical Pharmacology·H B FolkersG G Geyskes
Apr 1, 1990·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T M Hassell, A F Hefti
Jan 1, 1987·Fundamental & Clinical Pharmacology·C ThuillezJ F Giudicelli
Jan 1, 1985·Journal of Clinical Pharmacology·G MasottiL Poggesi
Apr 1, 1980·British Heart Journal·S KlugmannF Camerini
Sep 1, 1988·Anaesthesia·P ChariA Trikha
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·C E Hall, S Hungerford
Jan 1, 1982·Current Medical Research and Opinion·B L ChiaM Choo
Jan 1, 1980·European Journal of Clinical Pharmacology·M ThibonnierP Corvol
Jun 1, 2010·São Paulo Medical Journal = Revista Paulista De Medicina·Luciana Mendes SouzaAlvaro Nagib Atallah
Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·T S Tracy, C D Black

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.