Nifedipine and cancer mortality: ten-year follow-up of 2607 patients after acute myocardial infarction

Cardiovascular Drugs and Therapy
M JonasH Reicher-Reiss

Abstract

Recent publications contended that the use of short-acting calcium antagonists may double the risk of cancer incidence and possibly increase mortality in hypertensive patients. The purpose of this study was to assess the risk ratio for cancer mortality associated with nifedipine in a large population of patients post-myocardial infarction. Cancer mortality data, over a 10-year period, were obtained on 2607 hospital survivors of acute myocardial infarction who were screened, but not included, in the Secondary Prevention Reinfarction Israeli Nifedipine Trial (SPRINT I) study. In this group of patients, 526 (20%) were on nifedipine, according to their treating physicians' decision. In the cohort of screened patients not included in SPRINT I, there were 22 (4.2%) cancer-related deaths in the patients on nifedipine compared with 114 (5.5%) in the group not treated with nifedipine (P = 0.23). In multivariate analysis, the 10-year cancer mortality risk ratio associated with nifedipine therapy was 1.06 (95% CI 0.52-2.18). The current analysis shows no evidence of an increased risk of cancer mortality in a large number of patients treated at baseline with nifedipine.

Citations

May 11, 2002·Current Hypertension Reports·Ehud GrossmanUri Goldbourt
Sep 24, 2004·Dermatologic Therapy·Menno A de RieJan D Bos
Jun 21, 2013·International Journal of Cancer. Journal International Du Cancer·Alberto MilanFranco Veglio
Oct 26, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D C Felmeden, G Y Lip
Jun 26, 2008·Diseases of the Colon and Rectum·Antoni ZawadzkiHenrik Thorlacius
Sep 12, 2000·Current Hypertension Reports·E GrossmanU Goldbourt
Jun 23, 2006·Breast Cancer Research and Treatment·Jon P FryzekSøren Friis
Dec 12, 2012·Cancer Causes & Control : CCC·Babette S SaltzmanChristopher I Li
Dec 10, 1999·Journal of the American College of Cardiology·R P Mason

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