PMID: 9183921Jan 1, 1997Paper

Nifedipine and coronary insufficiency: reasons for controversy

Thérapie
M Lièvre, M Cucherat

Abstract

Meta-analyses of Furberg's original data (after correction of two minor errors) were performed using six different methods. Only three of them gave significant results at p < 0.05. The sensitivity analysis showed that taking into account some of the criticisms applied to the original meta-analysis did not change the results. When all the criticisms were considered together, the 95 per cent confidence interval of the odds ratio for mortality was [0.96; 1.31] instead of [1.06; 1.37] originally (p = 0.14 and p = 0.03 respectively), and the dose excess mortality relationship stressed by Furberg disappeared. When the selection of the studies to be entered in a meta-analysis is not straightforward, a sensitivity analysis should be performed.

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Related Papers

Cardiovascular Drugs and Therapy
P R Lichtlen
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
G L ShawM A Tucker
Current Atherosclerosis Reports
Sanjay Kaul, George A Diamond
© 2021 Meta ULC. All rights reserved