Nifedipine and hypertension: roles of vasodilation and sodium balance

Cardiovascular Drugs and Therapy
G A MacGregor

Abstract

Nifedipine reduces blood pressure predominantly by reducing systemic vascular resistance due to a direct vasodilating action on the arterioles. This peripheral vasodilation appears greater the more severe the hypertension. Nifedipine also causes a long-term loss of sodium, which may be an additive mechanism for the blood pressure fall. In patients who are not controlled on nifedipine alone, studies have demonstrated an additive effect of beta blockers and converting-enzyme inhibitors on blood pressure. There is controversy about whether diuretics have an additive effect on blood pressure in patients already on nifedipine.

References

Dec 18, 1978·European Journal of Clinical Pharmacology·O L Pedersen, E Mikkelsen
Dec 1, 1987·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·E P MacCarthy
Jan 1, 1987·American Journal of Nephrology·G A MacGregorN D Markandu
Oct 1, 1984·Journal of Hypertension·B F Robinson
Jan 1, 1982·European Journal of Clinical Pharmacology·S E HustedO Lederballe Pedersen
Jul 1, 1980·Journal of Cardiovascular Pharmacology·O Lederballe PedersenK D Rämsch
Jan 1, 1983·Journal of Cardiovascular Pharmacology·S Yokoyama, T Kaburagi
Jan 1, 1983·British Medical Journal·O BertelU C Dubach
Oct 1, 1982·British Journal of Clinical Pharmacology·S BayleyB F Robinson
Jan 1, 1982·European Journal of Clinical Pharmacology·R Eggertsen, L Hansson

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Citations

Aug 1, 1990·Cardiovascular Drugs and Therapy·A SalvettiR Giovannetti
Nov 19, 2019·Mini Reviews in Medicinal Chemistry·Abhinav Prasoon MishraAwani Kumar Rai

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