PMID: 2125296Nov 1, 1990Paper

Nifedipine antagonizes ouabain-induced ST-segment changes and derangement of epicardial activation pattern in isolated rabbit hearts

International Journal of Cardiology
S DheinW Klaus

Abstract

Isolated rabbit hearts, perfused according to the Langendorff technique were treated with 0.2 mumol/l ouabain or with a combination of 0.2 mumol/l ouabain and 3 nmol/l nifedipine. In a second series of experiments, a combination of 0.2 mumol/l ouabain with 0.2 mumol/l nitroglycerin was examined. Under this treatment, coronary flow and left ventricular pressure were continuously measured and, furthermore, the epicardial potential distribution was mapped with high temporal (4 kHz/channel) and spatial resolution (256 electrodes, arranged in 4 plates with 64 electrodes each, 8 x 8 matrix with 1 mm mesh size). Ouabain led to the expected positive inotropy of 10%, but also to a decrease in coronary flow of 15%. Besides these changes a nearly generalized ST-segment elevation could be observed. Moreover, the epicardial activation pattern was disturbed by changes in the location of epicardial breakthrough-points. Concomitantly, the epicardial activation vector field was deranged. Under the additional influence of nifedipine, coronary flow was reduced by only 5%, whereas the positive inotropic effect remained unchanged. The epicardial ST-elevation was diminished significantly and there was no derangement in the process of epicardial acti...Continue Reading

References

Aug 15, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M ZimpferG Raberger
Aug 1, 1985·Nature·H Reuter
Jan 1, 1986·Biomedica Biochimica Acta·B NiliusR W Tsien
Sep 1, 1986·Journal of Cardiovascular Pharmacology·F A JonkmanP A van Zwieten
Mar 1, 1988·Circulation Research·E G NabelT W Smith
May 1, 1988·Journal of Cardiovascular Pharmacology·J S Schwartz, R J Bache
Oct 1, 1985·Journal of Clinical Pharmacology·J C Somberg
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·L J Ignarro, P J Kadowitz
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·H J KramerM Sorger
Feb 1, 1986·Japanese Journal of Pharmacology·I Shimizu, N Toda
Dec 1, 1988·International Journal of Bio-medical Computing·S DheinW Klaus
Jan 1, 1974·The Journal of Clinical Investigation·N P HamlinW J Powell
Nov 1, 1983·Basic Research in Cardiology·B TörökT Simor
Jan 1, 1959·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·M H DRAPER, M MYA-TU

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Citations

Dec 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·S DheinW Klaus

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