Nifedipine can preserve renal function in patients undergoing aortic surgery with infrarenal crossclamping

Nephron
F AntonucciA D'Angelo

Abstract

Sixteen patients diagnosed with an aneurysm of abdominal aorta or Leriche disease underwent elective aortic surgery involving crossclamping of infrarenal aorta (ICC). These patients were randomized into two equal groups and 8 patients were infused with nifedipine starting from the isolation of aorta until the end of surgery (group A) while another 8 patients were infused with low-dose dopamine (group B) over the same surgical course. Plasma endothelin (ET) was measured before the induction of anesthesia, at the beginning and at the end of the clamp period and at the end of the operation. Intraoperatively, creatinine clearance and urinary excretion of PGE2, 6-keto PGF1 alpha and TxB2 were also determined before, during and after aortic crossclamping. Preoperative GFR as well as preinduction cardiac index (CI) and pulmonary capillary wedge pressure (PCWP) of the two groups did not differ. During cross-clamping plasma ET rose significantly in both groups. However, after clamp removal, plasma ET decreased in group A while it remained elevated in group B. Urinary excretion of TxB2, PGE2 and 6-keto PGF1 alpha increased during clamp in both groups, but the ratio of PGE2 + 6-keto PGF1 alpha/TxB2 during and after clamp was significantly...Continue Reading

Citations

Jul 20, 2006·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·H SchelzigL Sunder-Plassmann
Nov 30, 2000·Anesthesiology Clinics of North America·B C Weldon, T G Monk
Nov 30, 2000·Anesthesiology Clinics of North America·S Garwood
Aug 16, 2001·Critical Care Medicine·J A Kellum, J M Decker
Jan 1, 1997·Critical Care : the Official Journal of the Critical Care Forum·J A Kellum
Oct 3, 2006·Current Opinion in Anaesthesiology·G LemaJ Urzua
Nov 6, 2008·Clinics in Geriatric Medicine·Saira Noor, Ali Usmani
Oct 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Per-Olof Jarnberg
Jun 4, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J BownR D Sayers
Apr 27, 2012·Acta Cirúrgica Brasileira·André Marques MansanoYara Marcondes Machado Castiglia
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Mathew ZachariasNiamh P Conlon
Jul 5, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jason B O'NealFrederic T Billings
Aug 28, 2002·The Annals of Pharmacotherapy·Maria C Pruchnicki, Joseph F Dasta

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