PMID: 9161650May 1, 1997Paper

Nifedipine interaction with tacrolimus in liver transplant recipients

The Annals of Pharmacotherapy
R A SeifeldinR L Jenkins

Abstract

To examine the possible drug interaction between nifedipine and tacrolimus in liver transplant recipients. A retrospective study was done comparing two groups of liver transplant recipients. The starting time for comparison was the same after transplant. One group (n = 22) consisted of hypertensive patients who were treated with nifedipine; the other group (n = 28) did not receive nifedipine. The two groups were compared over 1 year. The effect of nifedipine on tacrolimus was measured in terms of tacrolimus whole blood trough concentrations, daily tacrolimus dosages, and cumulative tacrolimus dosages at 1, 3, 6, and 12 months. All patient charts were reviewed with regard to concurrent medication that could affect the metabolism of tacrolimus and eventually affect tacrolimus concentrations and dosages. All required information was retrieved from medical records. There was a statistically significant difference between daily dosage requirements of tacrolimus at 90 (p = 0.03), 180 (p = 0.004), and 365 (p = 0.0004) days between the nifedipine and no-nifedipine groups. The tacrolimus daily dosage in the nifedipine group was decreased by 26%, 29%, and 38% at 3, 6, and 12 months, respectively, compared with the dosage of the no-nifedi...Continue Reading

Citations

Aug 16, 2003·British Journal of Clinical Pharmacology·Dennis A HesselinkTeun van Gelder
Oct 31, 2003·Expert Opinion on Drug Safety·Renke Maas, Rainer H Böger
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