Nifedipine or nicardipine in management of threatened preterm delivery: an observational population-based study

Journal de gynécologie, obstétrique et biologie de la reproduction
Camille Le Raygroupe EVAPRIMA

Abstract

For the first line tocolysis, calcium channel blockers (CCB)--oral nifedipine (Adalate®) or intravenous nicardipine (Loxen®)--are frequently used in France. No study compared nifedipine and nicardipine in management of threatened preterm delivery. From data of a French observational study, we compared factors associated with the use of nifedipine and nicardipine. Efficacy and tolerance of the two treatments were also compared. It was a secondary analysis of EVAPRIMA study, a practice survey describing management of threatened preterm delivery in 107 French maternity units. Only women who received calcium channel blockers in their first line tocolytic therapy were included. We studied obstetrical factors associated with the choice of nifedipine or nicardipine. We also analyzed factors associated with a delivery within seven days following admission using univariate and multivariate analysis. Adverse secondary effects were compared between women who received nifedipine or nicardipine. Three hundred and four women received calcium channel blockers for their first line tocolytic therapy, in 73 maternity units: 93 (30.6%) women received oral nifedipine and 211 (69.4%) intravenous nicardipine. The same CCB was always prescribed in 69...Continue Reading

References

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Aug 10, 2000·Acta Obstetricia Et Gynecologica Scandinavica·V TsatsarisF Goffinet
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Nov 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·O ParantUNKNOWN EVAPRIMA Group
Mar 7, 2009·BMJ : British Medical Journal·Roel de HeusGerard H A Visser

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Citations

Mar 3, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·O ParantB Guyard-Boileau
Jul 23, 2015·BMC Oral Health·Stéphanie BaggioCarlos Madrid
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Ali MamaneGhislaine Bouvier

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