PMID: 9552815Feb 1, 1997Paper

Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients

Clinical Oral Investigations
J M ThomasonR A Seymour

Abstract

The prevalence and severity of gingival overgrowth in organ-transplant patients medicated with cyclosporin are greater in patients concomitantly medicated with nifedipine; however, no relationship between the gingival overgrowth and any of the nifedipine pharmacological variables has been demonstrated. The study examined the effect of five nifedipine pharmacological variables (nifedipine dosage, plasma concentration and gingival crevicular fluid concentration, M1 metabolite plasma concentration and the nifedipine: M1 ratio). The effect of the nifedipine variables on the gingival overgrowth score were examined using univariate and multivariate regression analysis. Adjustment for the effect of other risk factors was made by adding the distribution of each of the nifedipine variables in turn to a stepwise regression model containing previously identified risk factors for this condition. Despite the high levels of nifedipine sequestered in the GCF, only the plasma concentration of nifedipine was identified as a risk factor for the severity of gingival overgrowth in these patients (P = 0.01) once adjusted for other known risk factors (R2 for the model = 55%).

Citations

Nov 26, 2004·Journal of Periodontology·Anna Dongari-Bagtzoglou, UNKNOWN Research, Science and Therapy Committee, American Academy of Periodontology
Nov 1, 2007·Journal of Periodontology·A DrozdzikM Drozdzik
Jan 6, 2001·Journal of Clinical Periodontology·J S EllisJ M Thomason
Mar 16, 2005·Journal of Clinical Periodontology·J Mark ThomasonJanice S Ellis
Sep 16, 2004·Journal of Clinical Periodontology·J S EllisJ M Thomason
May 4, 2007·Periodontology 2000·Asvin Vasanthan, Nadeem Dallal
Apr 18, 2012·Periodontology 2000·Vivien KwokPaul G Hunter
Sep 26, 2009·Journal of Periodontal Research·A DrozdzikM Drozdzik
Sep 6, 2013·Journal of Dental Research·S S KimD W Hamilton
Jul 3, 2013·American Journal of Speech-language Pathology·Sharynne McLeodJane McCormack
Sep 24, 2005·Language, Speech, and Hearing Services in Schools·Brian A GoldsteinPatricia Swasey Washington
Oct 1, 2004·Journal of Periodontology
May 27, 2020·Analytical Cellular Pathology (Amsterdam)·Yanqin JuShouliang Zhao
Mar 5, 2020·Primary Dental Journal·Noha Zoheir, Francis J Hughes

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