PMID: 15384014Sep 24, 2004Paper

Night and day proteinuria in patients with sleep apnea

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Patricia MelloLawrence S Weisberg

Abstract

Previous studies have suggested an association between obstructive sleep apnea (OSA) and heavy proteinuria. Two recent studies cast doubt on the association between OSA and proteinuria, but neither studied the effect of disordered sleep per se on urinary protein excretion. We prospectively studied 75 patients undergoing polysomnography for suspected OSA. We excluded patients with renal insufficiency, diabetes mellitus, and systemic lupus erythematosus and those administered angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Urine protein-creatinine (P/C) ratio was measured on the date of the polysomnography before sleep (awake P/C ratio) and on awakening (asleep P/C ratio). Severity of OSA was stratified by means of the apnea-hypopnea index (AHI). Twenty-six patients (35%) did not have OSA, 25 patients (33%) had mild OSA, 9 patients (12%) had moderate OSA, and 15 patients (20%) had severe OSA. Asleep P/C ratio was less than 0.2 in 96% of patients, and awake P/C ratio was less than 0.2 in 89% of patients. No patient had an asleep P/C ratio greater than 1.0. There was no correlation between log asleep P/C ratio and log AHI ( r = -0.042; P = 0.73) or log awake P/C ratio and log AHI (r = 0.004; P = 0.97). No...Continue Reading

Citations

Sep 13, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Uwe KuhlmannHeinrich Friedrich Becker
Mar 18, 2015·Sleep & Breathing = Schlaf & Atmung·Emel BulcunUcler Kisa
Oct 1, 2014·European Journal of Clinical Investigation·Ian W SeethoJohn P H Wilding
Sep 26, 2013·Diabetes Care·Abd A TahraniMartin J Stevens
May 12, 2011·PloS One·Sofia B AhmedPatrick J Hanly
Mar 13, 2008·Sleep & Breathing = Schlaf & Atmung·Ahmet UrsavasR Oktay Gozu
Aug 3, 2010·Current Hypertension Reports·Gbemisola A Adeseun, Sylvia E Rosas
Jan 17, 2019·American Journal of Physiology. Renal Physiology·Julie O'NeillKen D O'Halloran
Apr 30, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Sylvia E Rosas
Jul 9, 2014·International Urology and Nephrology·Xiao-Bin ZhangHui-Qing Zeng
Jul 17, 2014·Sleep & Breathing = Schlaf & Atmung·Zehra Aşuk YaşarGültekin Tibet

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