Abstract
Shift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large population to the risk of circadian misalignment-driven disease. Analysis of the impact of shift work on chronic inflammatory diseases is lacking. We investigated the association between shift work and asthma. We describe the cross-sectional relationship between shift work and prevalent asthma in >280000 UK Biobank participants, making adjustments for major confounding factors (smoking history, ethnicity, socioeconomic status, physical activity, body mass index). We also investigated chronotype. Compared with day workers, 'permanent' night shift workers had a higher likelihood of moderate-severe asthma (OR 1.36 (95% CI 1.03 to 1.8)) and all asthma (OR 1.23 (95% CI 1.03 to 1.46)). Individuals doing any type of shift work had higher adjusted odds of wheeze/whistling in the chest. Shift workers who never or rarely worked on nights and people working permanent nights had a higher adjusted likelihood of having reduced lung function (FEV1 <80% predicted)...Continue Reading
References
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C M Spengler, S A Shea
Dec 13, 2005·The Journal of Allergy and Clinical Immunology·E Rand Sutherland
Apr 6, 2006·Cancer Causes & Control : CCC·Erhard Haus, Michael Smolensky
Jun 19, 2007·Lancet·Lyle J Palmer
Jun 7, 2008·Chronobiology International·Simon Folkard
May 3, 2011·PloS One·Karen L GambleCarl Hirschie Johnson
Apr 23, 2013·Journal of Biological Rhythms·Myriam JudaTill Roenneberg
Feb 21, 2014·Science Translational Medicine·Naomi E AllenUNKNOWN UK Biobank
Jan 6, 2015·Iranian Red Crescent Medical Journal·Mirsaeed AttarchiSeyed Mohammad Seyed Mehdi
Mar 17, 2015·Current Biology : CB·Céline VetterTill Roenneberg
Jun 17, 2016·Chronobiology International·Michael H SmolenskyFrancesco Portaluppi
Jul 6, 2016·International Archives of Occupational and Environmental Health·S JankowiakU Latza
Aug 30, 2016·BMC Medicine·Mome MukherjeeAziz Sheikh
May 26, 2017·American Journal of Epidemiology·Lani R WegrzynEva S Schernhammer
Jun 24, 2017·American Journal of Epidemiology·Anna FryNaomi E Allen
Sep 14, 2017·Nature Communications·Alexander C WestDavid A Bechtold
Dec 29, 2017·Chronobiology International·Jacek K UrbanekVadim Zipunnikov
Jan 16, 2018·Clinical & Translational Immunology·Cristina T VicenteManuel A R Ferreira
Feb 15, 2018·Diabetes Care·Céline VetterFrank A J L Scheer
Aug 30, 2018·American Journal of Respiratory and Critical Care Medicine·Hannah J DurringtonDavid W Ray
Dec 16, 2018·The Lancet. Respiratory Medicine·Nick ShrineIan Sayers
Aug 21, 2019·Trends in Endocrinology and Metabolism : TEM·Sarah L ChellappaFrank A J L Scheer
Jan 10, 2020·Diabetologia·Ivy C MasonFrank A J L Scheer
Jan 14, 2020·Sleep·Tracey L SlettenFrank A J L Scheer
Citations
Apr 28, 2021·Thorax·Robert MaidstoneJohn F Blaikley
Sep 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Frank A J L ScheerSteven A Shea
Oct 2, 2021·The Journal of Clinical Investigation·Anna B FishbeinPhyllis C Zee