Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

European Journal of Pharmacology
I Creese, S H Snyder


Following unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.


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