Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

European Journal of Pharmacology
I Creese, S H Snyder

Abstract

Following unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.

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Related Concepts

Bulla
Lentiform Nucleus Structure
Partial Lissencephaly
Substantia Nigra Structure
Hydroxydopamine
Butyrophenones
Dopamine Receptor
Tyrosine 3-Monooxygenase
Spiperone
Metazoa

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