NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity?

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
João Paulo B MachadoElizabeth P B Fontes

Abstract

NIK1 is a receptor-like kinase involved in plant antiviral immunity. Although NIK1 is structurally similar to the plant immune factor BAK1, which is a key regulator in plant immunity to bacterial pathogens, the NIK1-mediated defenses do not resemble BAK1 signaling cascades. The underlying mechanism for NIK1 antiviral immunity has recently been uncovered. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down-regulate translational machinery genes, resulting in translation inhibition of host and viral mRNAs and enhanced tolerance to begomovirus. Therefore, the NIK1 antiviral immunity response culminates in global translation suppression, which represents a new paradigm for plant antiviral defenses. Interestingly, transcriptomic analyses in nik1 mutant suggest that NIK1 may suppress antibacterial immune responses, indicating a possible opposite effect of NIK1 in bacterial and viral infections.

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Citations

Oct 27, 2016·Annals of Botany·Iara P Calil, Elizabeth P B Fontes
Feb 16, 2017·Genetics and Molecular Biology·João Paulo B MachadoElizabeth P B Fontes
Jan 21, 2017·Frontiers in Microbiology·Bianca C GouveiaElizabeth P B Fontes
Nov 20, 2018·Frontiers in Plant Science·Dinesh Babu Paudel, Hélène Sanfaçon
Apr 19, 2021·Current Opinion in Biotechnology·Elizabeth Pacheco Batista FontesRosa Lozano-Durán
May 1, 2021·Microorganisms·Ruan M TeixeiraElizabeth P B Fontes
Jun 3, 2021·Viruses·Marco Aurélio FerreiraElizabeth P B Fontes

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