PMID: 9192289Apr 1, 1997Paper

Nimodipine maintains in vivo the increase in GFAP and enhances the astroglial ensheathment of surviving motoneurons in the rat following permanent target deprivation

Journal of Neurocytology
O Guntinas-LichiusW F Neiss

Abstract

Facial and hypoglossal nerves were resected unilaterally in a total of 108 rats. Rats were divided into two groups; one group received standard food pellets (placebo), the other received food pellets containing the Ca(2+)-blocking agent nimodipine. The expression of glial fibrillary acidic protein was examined in paraffin sections of the brainstem using light microscopical immunocytochemistry, and the degree of glial process ensheathment of the surviving neuronal perikarya in the hypoglossal and facial nuclei quantified on electron micrographs. Up to 28 days post-axotomy no differences in glial fibrillary acidic protein-immunoreactivity were observed between placebo and nimodipine-treated animals. By 42-56 days, glial fibrillary acid protein-immunoreactivity was stronger in the nimodipine treated animals and by 112 days, glial fibrillary acid protein-immunoreactive astrocytes occurred only in nimodipine-treated animals. Thin astrocytic processes were seen to ensheath neurons in both placebo and nimodipine-treated animals. By 28 days post axotomy, lesioned neurons in nimodipine treated animals were covered by a mean of 2.6 (hypoglossal) and 2.9 (facial nucleus) astrocytic lamellae, compared with 1.7 lamellae in the placebo group...Continue Reading

Citations

Nov 13, 2001·Journal of Neurosurgery·C StraussJ Romstöck
Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joyce A DeLeoVivianne L Tawfik
Mar 17, 2004·The Journal of Urology·Francisco J Martinez PortilloKlaus P Juenemann
Dec 3, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Katja SygneckaHeike Franke
Jun 5, 2012·Neuropharmacology·Sadayuki HashiokaPatrick L McGeer
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Mar 13, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kevin ChorathKarthik Rajasekaran

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