Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Lorelei A MucciMark A Rubin

Abstract

Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.

Citations

Nov 29, 2012·Journal of Cancer Research and Clinical Oncology·Naveen Kachroo, Vincent J Gnanapragasam
Nov 13, 2012·Urologic Oncology·Maria Jesus Alvarez-CuberoJose Manuel Cozar
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