Nine-month angiographic and two-year clinical follow-up of novel biodegradable-polymer arsenic trioxide-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease

Chinese Medical Journal
Li ShenJunbo Ge

Abstract

Despite great reduction of in-stent restenosis, first-generation drug-eluting stents (DESs) have increased the risk of late stent thrombosis due to delayed endothelialization. Arsenic trioxide, a natural substance that could inhibit cell proliferation and induce cell apoptosis, seems to be a promising surrogate of sirolimus to improve DES performance. This randomized controlled trial was to evaluate the efficacy and safety of a novel arsenic trioxide-eluting stent (AES), compared with traditional sirolimus-eluting stent (SES). Patients with symptoms of angina pectoris were enrolled and randomized to AES or SES group. The primary endpoint was target vessel failure (TVF), and the second endpoint includes rates of all-cause death, cardiac death or myocardial infarction, target lesion revascularization (TLR) by telephone visit and late luminal loss (LLL) at 9-month by angiographic follow-up. From July 2007 to 2009, 212 patients were enrolled and randomized 1:1 to receive either AES or SES. At 2 years of follow-up, TVF rate was similar between AES and SES group (6.67% vs. 5.83%, P = 0.980). Frequency of all-cause death was significantly lower in AES group (0 vs. 4.85%, P = 0.028). There was no significant difference between AES and ...Continue Reading

References

Sep 18, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L SoignetR P Warrell
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Jul 26, 2008·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Mar 3, 2010·Nature Reviews. Cardiology·Rainer Wessely
Mar 31, 2012·International Journal of Cardiology·Yoshiyasu MinamiToshiaki Nakajima
May 23, 2012·Nature Reviews. Cardiology·Fumiyuki OtsukaRenu Virmani
Mar 26, 2013·JACC. Cardiovascular Interventions·Ajay J KirtaneUNKNOWN ENDEAVOR IV Investigators
May 25, 2013·JACC. Cardiovascular Interventions·Michael A Kutcher

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Methods Mentioned

BETA
coronary artery bypass
pregnancy test

Software Mentioned

SAS
R

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Apoptosis

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