Nine Things Genomics Can Tell Us About Candida auris.

Frontiers in Genetics
Aleksandra D ChybowskaRhys A Farrer

Abstract

Candida auris is a recently emerged multidrug-resistant fungal pathogen causing severe illness in hospitalized patients. C. auris is most closely related to a few environmental or rarely observed but cosmopolitan Candida species. However, C. auris is unique in the concern it is generating among public health agencies for its rapid emergence, difficulty to treat, and the likelihood for further and more extensive outbreaks and spread. To date, five geographically distributed and genetically divergent lineages have been identified, none of which includes isolates that were collected prior to 1996. Indeed, C. auris' ecological niche(s) and emergence remain enigmatic, although a number of hypotheses have been proposed. Recent genomic and transcriptomic work has also identified a variety of gene and chromosomal features that may have conferred C. auris with several important clinical phenotypes including its drug-resistance and growth at high temperatures. In this review we discuss nine major lines of enquiry into C. auris that big-data technologies and analytical approaches are beginning to answer.

References

Jul 1, 1993·Journal of Clinical Microbiology·P F LehmannD G Ahearn
Jan 1, 1995·Emerging Infectious Diseases·S S Morse
Aug 7, 1998·International Journal of Sports Medicine·M Gleeson
May 2, 2000·Journal of Clinical Microbiology·B GrafU B Göbel
Jan 1, 1962·Antonie van Leeuwenhoek· van UDEN, M C KOLIPINSKI
May 25, 2004·Antimicrobial Agents and Chemotherapy·Andrew R DodgsonDavid R Soll
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·W LaJean Chaffin
Sep 3, 2009·The Annals of Pharmacotherapy·Allana J SucherHolly E Balcer
Aug 7, 2010·MBio·Monica A Garcia-Solache, Arturo Casadevall
Dec 1, 2010·Eukaryotic Cell·Yaoping Liu, Scott G Filler
Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Aug 9, 2011·Comptes rendus biologies·Manuel A S SantosGabriela R Moura
Sep 21, 2011·PLoS Pathogens·Nicole RobbinsLeah E Cowen
Jan 2, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Majeda S HammoudZiauddin Khan
Jan 11, 2013·Virulence·François L MayerBernhard Hube
Sep 26, 2013·Future Microbiology·Heather T TaffDavid R Andes
Jan 8, 2014·Clinical Microbiology Reviews·Timothy FeltonWilliam W Hope
Jun 19, 2014·PloS One·Shahida ShahanaAlistair J P Brown
Apr 18, 2015·Journal of Infection in Developing Countries·Dharmendra KumarRagini Tilak
Apr 26, 2015·Advances in Applied Microbiology·Melanie PolkeIlse D Jacobsen
Sep 9, 2015·BMC Genomics·Sharanya ChatterjeeUtpal S Tatu
Sep 20, 2015·Medical Mycology·Michael A Pfaller, Mariana Castanheira
Nov 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel Aguilar-ZapataVidmantas Petraitis
Mar 11, 2016·Pathogens and Disease·Christina TsuiMary Ann Jabra-Rizk
Aug 23, 2016·Frontiers in Microbiology·Cécile GarnaudJérôme Govin
Aug 26, 2016·Nature·Nerilie J AbramUNKNOWN PAGES 2k Consortium
Oct 22, 2016·Medical Mycology Case Reports·Antonio Carlos BandeiraKarine de Almeida Ramos

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Citations

Sep 26, 2020·Journal of Fungi·Elizabete de Souza CândidoOctavio Luiz Franco
Sep 6, 2020·Antibiotics·María Guadalupe Frías-De-LeónErick Martínez-Herrera
Dec 17, 2020·MBio·Megha Sharma, Arunaloke Chakrabarti
Mar 20, 2021·Probiotics and Antimicrobial Proteins·Konstantin A DeminMichael L Chikindas
May 1, 2021·International Journal of Molecular Sciences·Lucia ČernákováCélia F Rodrigues
Dec 25, 2021·Journal of the Pediatric Infectious Diseases Society·Alexander L Greninger, Danielle M Zerr
Oct 24, 2020·Microbiological Research·Gustavo Bravo Ruiz, Alexander Lorenz

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Methods Mentioned

BETA
Illumina sequencing
histone acetylation
gene knock out

Software Mentioned

RapID Yeast Plus
VITEK
BD Phoenix

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