Ninety-day inhalation toxicity study with a vapor grown carbon nanofiber in rats

Toxicological Sciences : an Official Journal of the Society of Toxicology
Michael P DeLormeDavid B Warheit

Abstract

A subchronic inhalation toxicity study of inhaled vapor grown carbon nanofibers (CNF) (VGCF-H) was conducted in male and female Sprague Dawley rats. The CNF test sample was composed of > 99.5% carbon with virtually no catalyst metals; Brunauer, Emmett, and Teller (BET) surface area measurements of 13.8 m2/g; and mean lengths and diameters of 5.8 µm and 158 nm, respectively.Four groups of rats per sex were exposed nose-only, 6 h/day, for 5 days/week to target concentrations of 0, 0.50, 2.5, or 25 mg/m3 VGCF-H over a 90-day period and evaluated 1 day later. Assessments included conventional clinical and histopathological methods, bronchoalveolar lavage fluid (BALF) analysis, and cell proliferation (CP) studies of the terminal bronchiole (TB), alveolar duct (AD), and subpleural regions of the respiratory tract. In addition, groups of 0 and 25 mg/m3 exposed rats were evaluated at 3 months postexposure (PE). Aerosol exposures of rats to 0.54 (4.9 f/cc), 2.5 (56 f/cc), and 25 (252 f/cc) mg/m(3) of VGCF-H CNFs produced concentration-related small, detectable accumulation of extrapulmonary fibers with no adverse tissue effects. At the two highest concentrations, inflammation of the TB and AD regions of the respiratory tract was noted w...Continue Reading

References

Sep 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chiu-Wing LamRobert L Hunter
Sep 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·D B WarheitT R Webb
Sep 1, 2005·Toxicology and Applied Pharmacology·Julie MullerDominique Lison
Feb 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ken DonaldsonAndrew Alexander
Sep 28, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dominique Lison, Julie Muller
Jul 9, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lan Ma-HockRobert Landsiedel
Sep 29, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·David B Warheit
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Vanesa C SanchezAgnes B Kane

❮ Previous
Next ❯

Citations

Dec 22, 2015·Regulatory Toxicology and Pharmacology : RTP·Josje H E ArtsRobert Landsiedel
Sep 13, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Günter OberdörsterPhil Sayre
Aug 7, 2013·Nanotoxicology·Srinivas AalapatiBalakrishna Murthy Prakya
Mar 31, 2015·Regulatory Toxicology and Pharmacology : RTP·Josje H E ArtsRobert Landsiedel
Aug 11, 2017·Journal of Occupational Health·Norihiro KobayashiYasuo Morimoto
Mar 22, 2014·Chemical Society Reviews·Yi ZhangBing Yan
Oct 1, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jessica L RayAndrij Holian
Dec 14, 2017·International Journal of Molecular Sciences·Yue-Wern HuangHan-Jung Lee
Nov 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna A ShvedovaVincent Castranova
Oct 21, 2020·Nanomaterials·Chinatsu NishidaYasuo Morimoto
Feb 26, 2021·Journal of Toxicologic Pathology·Takamasa NumanoYuji Hagiwara
Apr 4, 2021·Nanomaterials·Enrico BergamaschiIrina Guseva Canu
May 26, 2021·The Science of the Total Environment·Abraão Tiago Batista Guimarães, Guilherme Malafaia
Aug 8, 2021·International Journal of Molecular Sciences·Katarzyna Lisik, Anita Krokosz
Apr 12, 2014·Chemical Reviews·Naoto SaitoMorinobu Endo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.