PMID: 16538039Mar 16, 2006Paper

Ninety-day toxicity and one-generation reproduction study in rats exposed to allethrin-based liquid mosquito repellent

The Journal of Toxicological Sciences
Anvita SrivastavaRajendra Behari Raizada

Abstract

Rats exposed to liquid mosquito repellent (LMR) containing allethrin (3.6% w/w) 8-hrs/ day for a period of ninety days did not produce any signs of toxicity or death. Significant increases in relative weight of liver and adrenal in males, brain and thyroid in females were observed. No significant changes were noticed in clinical enzyme profile, gonadal enzymes and histopathology of vital organs except mild changes in the activities of liver and serum alkaline phosphates (ALP), testicular glucose-6-phosphate dehydrogenase (G-6PDH) and epididymal sorbitol dehydrogenase (SDH). Rats exposed to LMR for one generation had not produced changes in their reproductive indices such as fertility index, gestation index, live pups/ dam and sex ratio. There was no change in the preweanling evaluation of pups such as survival and growth index on post-natal days (PND) 0, 4, 7,14 and 21. No significant pathomorphological changes were observed in liver, brain, kidney and gonads of PND 21 pups. Absences of any major adverse effects in the adult as well as weanling rats suggest the safe use of allethrin-based LMR.

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Citations

Mar 25, 2011·Toxicology International·G K SanghaBalwinder Singh
Apr 25, 2014·Pesticide Biochemistry and Physiology·Morteza MolaviHamed Rezaie
Oct 13, 2007·Digestive Diseases and Sciences·Ken-Ichi MukaishoTakanori Hattori
Mar 17, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mian WangBaohua Xu
Jul 10, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinSusan R Woskie
Oct 20, 2011·The Journal of Toxicological Sciences·Hasan Türkez, Başak Toğar
Jul 30, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Golla Madhubabu, Suresh Yenugu
May 10, 2019·Journal of Microencapsulation·Çiğdem Yücelİsmail Tuncer Değim

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