Ninjurin1: a potential adhesion molecule and its role in inflammation and tissue remodeling

Molecules and Cells
Hyo-Jong LeeKyu-Won Kim

Abstract

Nerve injury induced protein 1, Ninj1 (Ninjurin1) is a cell surface protein that is induced by nerve injury and promotes axonal growth in the peripheral nervous system. However, the function of Ninj1 in the vascular system and central nervous system (CNS) is incompletely understood. Here we review recent studies that have shed further light on the role and regulation of Ninj1 in vascular remodeling and inflammation. Increasing evidence suggests that Ninj1 mediates cell communication and enhances the entry, migration, and activity of leukocytes such as monocytes and macrophages in developmental processes and inflammatory responses. Moreover, our recent studies show that Ninj1 regulates close interaction between leukocytes and vascular endothelial cells in vascular remodeling and inflamed CNS. Additionally, Ninj1 enhances the apoptosis-inducing activity of leukocytes and is cleaved by MMPs, resulting in loss of adhesion during tissue remodeling. The collective data described here show that Ninj1 is required for the entry, adhesion, activation, and movement of leukocytes during tissue remodeling and might be a potential therapeutic target to regulate the adhesion and trafficking of leukocytes in inflammation and leukocyte-mediated...Continue Reading

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Citations

Apr 11, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hyo-Jong Lee, Kyu-Won Kim
Jun 15, 2012·Biomolecular NMR Assignments·In-Gyun LeeBong-Jin Lee
Oct 16, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Su Jung HwangKyu-Won Kim
May 25, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Su Jung HwangYoumie Park
Feb 14, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Carla R GraçaAndréa R Baptista Rossit
Jan 10, 2017·Journal of Cellular Biochemistry·Sung-Jin BaeKyu-Won Kim
Dec 18, 2015·International Journal of Oncology·Min Wook ShinKyu-Won Kim
Jan 23, 2016·The Journal of Biological Chemistry·Yichun QiaoKarin Dahlman-Wright
Jan 18, 2020·Anatomy & Cell Biology·Poornima EkanayakeTaekyun Shin
Dec 16, 2020·Neural Regeneration Research·Poornima D E Weerasinghe-MudiyanselageMeejung Ahn

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