Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Hoon ChoiKyu-Won Kim


Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage polarization and dysbiosis contributes to inflammatory bowel disease (IBD) pathogenesis. However, the molecular factors mediating colonic homeostasis are not well characterized. Here, we found that Ninjurin1 (Ninj1) limits colon inflammation by regulating macrophage polarization and microbiota composition under homeostatic conditions and during colitis development. Ninj1 deletion in mice induced hypersusceptibility to colitis, with increased prevalence of colitogenic Prevotellaceae strains and decreased immunoregulatory Lachnospiraceae strains. Upon co-housing (CoH) with WT mice, Ninj1-/- mice showed increased Lachnospiraceae and decreased Prevotellaceae abundance, with subsequent improvement of colitis. Under homeostatic conditions, M1 macrophage frequency was higher in the Ninj1-/- mouse colons than wild-type (WT) mouse colons, which may contribute to increased basal colonic inflammation and microbial imbalance. Following colitis induction, Ninj1 expression was increased in macrophages; meanwhile Ninj1-/- mice showed severe colitis development and impaired recovery, associated with decreased M2 macrophages and escalated microbial imbalance. In vitro, Ninj1 ...Continue Reading


Jan 1, 1981·Laboratory Animals·C Moolenbeek, E J Ruitenberg
Aug 22, 1997·The Journal of Biological Chemistry·T ArakiJ Milbrandt
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·B SiegmundC A Dinarello
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie BenoitJean-Louis Mege
Jan 5, 2010·Gastroenterology·Meaghan M HunterDerek M McKay
Oct 29, 2010·The ISME Journal·Gerardo M NavaThaddeus S Stappenbeck
Feb 2, 2012·Inflammatory Bowel Diseases·Stéphane NahonJean-Pierre Gendre
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Jun 26, 2012·Nature Reviews. Immunology·Richard L Gallo, Lora V Hooper
Aug 7, 2012·Cell Host & Microbe·Frederic A CarvalhoAndrew T Gewirtz
Oct 26, 2012·The Journal of Pathology·Alberto MantovaniMassimo Locati
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Seong-Jun ChoXinbin Chen
Dec 19, 2013·The Journal of Biological Chemistry·Bum Ju AhnKyu-Won Kim
Jan 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Pamela V ChangRuslan Medzhitov
Feb 25, 2014·Gastroenterology·Aleksandar D KosticDirk Gevers
Mar 29, 2014·F1000prime Reports·Fernando O Martinez, Siamon Gordon
Apr 1, 2014·Cell·Yasmine Belkaid, Timothy W Hand
Apr 15, 2014·Cellular & Molecular Immunology·Yuli LinRui He
Oct 14, 2014·FEBS Letters·William A WaltersRob Knight
Dec 20, 2014·Cell Death and Differentiation·L LiD P Lane
Apr 11, 2015·American Journal of Respiratory Cell and Molecular Biology·Carla JenneweinKai Zacharowski
Dec 18, 2015·International Journal of Oncology·Min Wook ShinKyu-Won Kim
Mar 18, 2016·Immunity·Stefan H E Kaufmann, Anca Dorhoi
May 28, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Raymond A Isidro, Caroline B Appleyard
Aug 25, 2016·Mucosal Immunology·M Y ZengG Nuñez
Nov 7, 2016·Molecular Neurobiology·Hoang LeKyu-Won Kim
Nov 24, 2016·Nature Communications·Walid MottaweaAlain Stintzi
Mar 7, 2017·Nature Reviews. Immunology·Maayan LevyEran Elinav
Apr 23, 2017·Cellular Signalling·Jingjing WangChengqi Xu
Jun 20, 2017·Cell Metabolism·Thomas Siegmund Postler, Sankar Ghosh
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hee Jung YangXinbin Chen

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