Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes

Circulation Journal : Official Journal of the Japanese Circulation Society
Motoki MatsukiJun-ichi Kawabe

Abstract

Capillary pericytes (cPCs), the mural cells of microvessels, play an important role in the formation and maintenance of microvessels; however, little is known about the mechanisms of how cPCs regulate angiogenesis. To identify factors that modulate cPC function, genes whose levels were altered in cPCs during neovessel formation were identified through a microarray screen. Ninjurin1 (nerve injury-induced protein, Ninj1) was selected as a candidate factor for angiogenesis regulation. Ninj1 was expressed in capillary cells including endothelial cells (cECs) and was expressed at a higher level in cPCs. Hypoxia induced the gene expression of Ninj1 in addition of vascular endothelial growth factor (VEGF) in cPCs. When cPCs were co-incubated with a thoracic aorta in a three-dimensional Matrigel system, the length of the EC-tubes sprouting from the aorta was increased. Small interfering RNA-mediated downregulation of Ninj1 in cPCs enhanced these cPCs-mediated angiogenic effects, whereas overexpression of Ninj1 attenuated their effects. The production of angiogenic growth factors, such as VEGF and angiopoietin 1, by cPCs was enhanced by the downregulation of Ninj1, and reduced by the overexpression of Ninj1. Ninj1 is a novel regulator f...Continue Reading

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Citations

May 8, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuyuki Fujita, Atsuhiko Kawamoto
Nov 7, 2016·Molecular Neurobiology·Hoang LeKyu-Won Kim
Nov 12, 2016·Translational Stroke Research·Wei CaiXiaoming Hu
May 10, 2017·Journal of Tissue Engineering and Regenerative Medicine·Nurlan MansurovArman Saparov
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hee Jung YangXinbin Chen
Sep 1, 2019·Stem Cells Translational Medicine·Yuri YoshidaJun-Ichi Kawabe
Dec 18, 2015·International Journal of Oncology·Min Wook ShinKyu-Won Kim
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Akiho MinoshimaJun-Ichi Kawabe
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tanya Gandhi, Charles C Lee
May 8, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Kiwamu HoriuchiJun-Ichi Kawabe

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