Nintedanib antiangiogenic inhibitor effectiveness in delaying adenocarcinoma progression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

Journal of Biomedical Science
Raquel Frenedoso da SilvaValéria Helena Alves Cagnon

Abstract

In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular proliferation. One such drug is Nintedanib; the present study evaluated the effectiveness of Nintedanib treatment against in vitro proliferation of human prostate cancer (PCa) cell lines, and growth and progression of different grades of PCa lesions in pre-clinical PCa transgenic adenocarcinoma for the mouse prostate (TRAMP) model. Both androgen-independent (LNCaP) and androgen-dependent (PC3) PCa cell lines were treated with a range of Nintedanib doses for 72 h, and effect on cell growth and expression of angiogenesis associated VEGF receptors was analyzed. In pre-clinical efficacy evaluation, male TRAMP mice starting at 8 and 12 weeks of age were orally-fed with vehicle control (10% Tween 20) or Nintedanib (10 mg/Kg/day in vehicle control) for 4 weeks, and sacrificed immediately after 4 weeks of drug treatment or sacrificed 6-10 weeks after stopping drug treatments. At the end of treatment schedule, mice were sacrificed and ventral lobe of prostate was excised along with essential metabolic organ liver, and subjected to histopath...Continue Reading

References

Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
May 10, 2000·The Oncologist·G McMahon
Oct 6, 2000·Endocrine-related Cancer·C J PowersA Wellstein
Apr 15, 2003·The Prostate·Paula J Kaplan-LefkoNorman M Greenberg
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 4, 2007·The Journal of Pathology·K SahadevanV J Gnanapragasam
Jul 25, 2008·Nature Reviews. Cancer·Gabriele Bergers, Douglas Hanahan
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuanjie NiuChawnshang Chang
Apr 21, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Silvia HernándezJosep Lloreta
May 6, 2009·Journal of Cellular Biochemistry·Maija P ValtaPirkko L Härkönen
Jun 2, 2009·Seminars in Cancer Biology·Vanessa Baeriswyl, Gerhard Christofori
Mar 11, 2010·Journal of Cancer Research and Clinical Oncology·Li PanChun-Ting Wang
Dec 7, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kanae KudoKazuto Nishio
Jan 14, 2011·Toxicologic Pathology·Bob ThoolenJerrold M Ward
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Feb 9, 2012·Current Oncology Reports·Gennaro DanieleJohann S de Bono
Aug 30, 2012·Endocrine-related Cancer·David A Barron, David R Rowley
Nov 15, 2012·International Journal of Hepatology·Géraldine GentricSéverine Celton-Morizur
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul G CornNora Navone
Dec 18, 2013·The Prostate·Eun-Ryeong HahmShivendra V Singh
Dec 24, 2013·Histochemistry and Cell Biology·A C HetzlV H A Cagnon
Apr 4, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Nov 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pengfei YuJingwei Tian
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Sep 22, 2018·Cell Biology International·Túlio de Almeida HermesElaine Minatel
Sep 2, 2019·Cell and Tissue Research·Raquel Frenedoso da SilvaValéria Helena Alves Cagnon
Jul 31, 2020·Physiological Reviews·Arianna GiacominiMarco Presta
Jun 30, 2019·Cell Biology and Toxicology·Clara H LeeRussell S Taichman
Mar 13, 2020·Scientific Reports·Min-Jeong HeoJin Hyuk Jung
Aug 3, 2021·Journal of Food Biochemistry·Andressa Mara BaseggioMário Roberto Maróstica Júnior

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Methods Mentioned

BETA
transgenic
electrophoresis

Software Mentioned

Gene Sys
Nuvilab
Adobe Photoshop
GraphPad Prism
Image J ( Image Analysis and Processing in Java )

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