Nintedanib in patients with progressive fibrosing interstitial lung diseases-subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial

The Lancet. Respiratory Medicine
Athol U WellsINBUILD trial investigators

Abstract

The INBUILD trial investigated the efficacy and safety of nintedanib versus placebo in patients with progressive fibrosing interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis (IPF). We aimed to establish the effects of nintedanib in subgroups based on ILD diagnosis. The INBUILD trial was a randomised, double-blind, placebo-controlled, parallel group trial done at 153 sites in 15 countries. Participants had an investigator-diagnosed fibrosing ILD other than IPF, with chest imaging features of fibrosis of more than 10% extent on high resolution CT (HRCT), forced vital capacity (FVC) of 45% or more predicted, and diffusing capacity of the lung for carbon monoxide (DLco) of at least 30% and less than 80% predicted. Participants fulfilled protocol-defined criteria for ILD progression in the 24 months before screening, despite management considered appropriate in clinical practice for the individual ILD. Participants were randomly assigned 1:1 by means of a pseudo-random number generator to receive nintedanib 150 mg twice daily or placebo for at least 52 weeks. Participants, investigators, and other personnel involved in the trial and analysis were masked to treatment assignment until after database lock. In th...Continue Reading

Citations

Mar 29, 2020·The European Respiratory Journal·Kevin K BrownAthol U Wells
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
Jul 14, 2020·Current Opinion in Pulmonary Medicine·Jelle R MiedemaPaolo Spagnolo
Jul 14, 2020·Current Opinion in Pulmonary Medicine·Amornpun WongkarnjanaMartin R J Kolb
Jul 24, 2020·Current Opinion in Pulmonary Medicine·Pierre-Antoine JugePhilippe Dieudé
Jul 2, 2020·Annals of the American Thoracic Society·Francesco VaroneLuca Richeldi
Jun 23, 2020·Expert Review of Respiratory Medicine·Paroma SarkarNazia Chaudhuri
Oct 4, 2020·Expert Review of Clinical Pharmacology·Bénédict Fallet, Ulrich A Walker
Nov 11, 2020·Virchows Archiv : an International Journal of Pathology·Stijn E VerledenDanny Jonigk
Jan 21, 2021·Current Opinion in Pulmonary Medicine·Christopher C Huntley, Gareth I Walters
Jan 30, 2021·Deutsche medizinische Wochenschrift·Philipp MarkartMalgorzata Wygrecka
Sep 6, 2020·The Lancet. Respiratory Medicine·Peter M GeorgeUNKNOWN Erice ILD working group
Feb 5, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Tadafumi Yokoyama, Bernadette R Gochuico
Jan 8, 2021·Nature Reviews. Rheumatology·Athol U Wells
Feb 28, 2021·Occupational and Environmental Medicine·Eerika KeskitaloRiitta Kaarteenaho
Mar 10, 2021·Lung India : Official Organ of Indian Chest Society·Antonio Vitiello, Francesco Ferrara
Mar 18, 2021·Respiratory Research·Vincent CottinUNKNOWN INBUILD Trial Investigators
Mar 30, 2021·ACR Open Rheumatology·Flavia V Castelino, Teng Moua
Apr 4, 2021·Pharmaceuticals·Eun Ha Kang, Yeong Wook Song
Jul 6, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Shamma Ahmad Al NokhathaRichard Conway
Apr 12, 2021·Best Practice & Research. Clinical Rheumatology·Maria Martin-Lopez, Patricia E Carreira
Apr 22, 2021·Expert Opinion on Drug Safety·Giacomo SgallaLuca Richeldi
Apr 30, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alan K Y Teoh, Tamera J Corte
May 25, 2021·Clinics in Chest Medicine·Leticia Kawano-Dourado, Joyce S Lee
May 25, 2021·Clinics in Chest Medicine·Hayley Barnes, Kerri A Johannson
May 25, 2021·Clinics in Chest Medicine·Bridget F Collins, Fabrizio Luppi
Apr 10, 2021·American Journal of Respiratory and Critical Care Medicine·Anna J PodolanczukOliver Eickelberg
Jun 3, 2021·Journal of Clinical Medicine·John N ShumarChristopher S King

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Kevin R FlahertyINBUILD trial investigators
The New England Journal of Medicine
Oliver DistlerSENSCIS Trial Investigators
© 2021 Meta ULC. All rights reserved