PMID: 8961159Nov 1, 1996Paper

Niosomal plumbagin with reduced toxicity and improved anticancer activity in BALB/C mice

The Journal of Pharmacy and Pharmacology
R A NareshP U Devi

Abstract

Plumbagin niosome were prepared using a lipid layer hydration method, and drug entrapment was measured. The acute toxicity studies were conducted following treatment with free and niosomal plumbagin. The antitumour activity of niosomal plumbagin in a solid tumor (sarcoma-180) and Ehrlich ascites model was evaluated. Niosome-encapsulated plumbagin was less toxic than free drug. The antitumour activity of the drug was also better after encapsulation. The better anticancer activity can be justified with the help of LD50 survival studies and study of tumour volume doubling time.

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Citations

Nov 2, 2004·Planta·Srinivasan SowmyalakshmiDamodaran Chendil
Oct 3, 2014·Pharmacognosy Research·Alexander Ronaldo AnufSureshkumar Periyasamy
Dec 13, 2002·Drug Development and Industrial Pharmacy·A BalasubramaniamK Sadasivan Pillai
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·Yaxian DingChung-Ho Chang
Apr 28, 2010·European Journal of Pharmacology·Su-Jung YangChung-Ho Chang
Jan 7, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jemal DemmaBjörn Hellman
Nov 2, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Aik Kia KhawM Prakash Hande
Nov 5, 2008·Journal of Cellular Biochemistry·Aamir AhmadFazlul H Sarkar
Oct 13, 2012·Medicinal Research Reviews·Subhash PadhyeFazlul H Sarkar
Sep 3, 2016·International Journal of Pharmaceutics·Tamer ShehataKen-Ichi Ogawara
Apr 1, 2017·The American Journal of Chinese Medicine·Yuling LiuHui Li
Oct 12, 2007·Phytochemical Analysis : PCA·Tomás GrevenstukAnabela Romano
Jul 21, 2004·Molecular Carcinogenesis·Priya SrinivasGopal Srinivas
Jan 5, 2018·Artificial Cells, Nanomedicine, and Biotechnology·S RajalakshmiBothiraja Chellampillai
Jul 26, 2019·Journal of Interdisciplinary Nanomedicine·Intouch SakpakdeejaroenChristine Dufès
Dec 5, 2021·Journal of Materials Science. Materials in Medicine·Mahmood BaraniFrancesco Baino

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