Nipple-sparing mastectomy: external validation of a three-dimensional automated method to predict nipple occult tumour involvement on preoperative breast MRI

European Radiology Experimental
Marta D'AlonzoNicoletta Biglia

Abstract

Preoperative evaluation of nipple-areola complex (NAC) tumour involvement is crucial to select patients candidates for nipple-sparing mastectomy. Our aim was to validate a previously developed automated method able to compute the three-dimensional (3D) tumour-to-NAC distance (the most predictive parameter of nipple involvement), using magnetic resonance imaging (MRI) datasets acquired with a scanner and protocol different from those of the development phase. We performed a retrospective analysis of 77 patients submitted to total mastectomy and preoperatively studied with MRI. The new method consisted of automated segmentation of both NAC and tumour and subsequent computation of the 3D distance between them; standard manual two-dimensional segmentation was independently performed. Paraffin-embedded section examination of the removed NAC was performed to identify the neoplastic involvement. The ability of both methods to discriminate between patients with and without NAC involvement was compared using receiver operating characteristic (ROC) analysis. The 3D tumour-to-NAC distance was correctly computed for 72/77 patients (93.5%); tumour and NAC segmentation method failed in two and three cases, respectively. The diagnostic perfor...Continue Reading

References

Jan 22, 2008·American Journal of Surgery·Margaret J LoewenTimothy L Fitzgerald
Mar 23, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Francesco SardanelliRobin Wilson
Nov 26, 2010·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Valentina GianniniDaniele Regge
Oct 4, 2011·Journal of Magnetic Resonance Imaging : JMRI·Anna VignatiFrancesco Sardanelli
Jan 11, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Y PetitM Rietjens
Jun 1, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marta D'AlonzoRiccardo Ponzone
Jul 26, 2013·AJR. American Journal of Roentgenology·Ji Yoon MoonDae Young Seo
Jan 1, 2014·Annals of Plastic Surgery·Zdenko StanecGorjanc Božo
Jan 11, 2014·Frontiers in Neuroinformatics·Nicholas J Tustison, Brian B Avants
Apr 22, 2015·Breast Cancer Research and Treatment·Hanwen ZhangQifeng Yang
Jul 27, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Riccardo PonzoneLaura Martincich
Mar 25, 2016·AJR. American Journal of Roentgenology·José Roberto Morales PiatoJosé Roberto Filassi
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Y PetitM Rietjens

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