PMID: 590849Nov 1, 1977

Nippostronglylus brasiliensis infection in the rat: effect of iron and protein deficiency and dexamethasone on the efficacy of benzimidazole anthelmintics

Gut
V M DuncombeJ D Kelly

Abstract

Malnutrition, anaemia, and gut parasites are commonly interrelated. Using the Nippostrongylus brasiliensis-rat model, the effect of iron and protein deficiency on the efficacy of benzimidazole anthelmintics was studied. It was demonstrated that the anthelmintics mebendazole and fenbendazole were significantly less effective in eradicating parasites when animals were deficient in iron and protein. This decreased efficacy of anthelmintics in iron and protein deficiency could not be overcome by intraperitoneal administration of the drug. Since nutritional deficiencies may act via impairment of the immune response, anthelmintic efficacy was determined in adequately nourished rats treated with the immunosuppressive drug dexamethasone. A similar decrease in efficacy of mebendazole was shown when these animals were treated with dexamethasone. Thus it is possible that lowered anthelmintic efficacy in iron and protein deficient animals is mediated by immune deficiency. These findings may be relevant to anthelmintic programmes in malnourished communities.

References

Sep 1, 1976·Australian Veterinary Journal·J D Kelly, J K Dineen
May 10, 1975·British Medical Journal·J G HutchisonC Aidney
Dec 4, 1974·JAMA : the Journal of the American Medical Association·M S Wolfe, J M Wershing
Dec 4, 1974·JAMA : the Journal of the American Medical Association·J D Archer
Jan 1, 1973·International Archives of Allergy and Applied Immunology·J D KellyR J Love
Sep 1, 1973·The American Journal of Tropical Medicine and Hygiene·A P ChavarríaR Zeledón
Feb 1, 1970·Annals of Internal Medicine·E RiveraG Malaret
Jul 19, 1971·JAMA : the Journal of the American Medical Association·J P BrugmansH L Lauwers
Nov 17, 1966·The New England Journal of Medicine·T CruzH Rocha

Citations

Oct 1, 1991·International Journal for Parasitology·G R RajasekariahS Bose
May 26, 2001·Annual Review of Nutrition·K G Koski, M E Scott
Feb 9, 2012·Veterinary Parasitology·Jessica SiegA Fischer
May 4, 2007·Journal of Chemical Ecology·Mei-Hwei TsengYueh-Hsiung Kuo
Apr 1, 1984·Annals of Tropical Medicine and Parasitology·J F Rossignol, H Maisonneuve

Related Concepts

Benzimidazoles
Oradexon
Diet
Panacur
Iron
Vermin
Nematode Infections
Rat Nematode
Protein Deficiency

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