NIR-Activated Polydopamine-Coated Carrier-Free "Nanobomb" for In Situ On-Demand Drug Release

Advanced Science
Minghui LiWenguang Liu

Abstract

Carrier-free nanoparticles with high drug loading have attracted increasing attention; however, in situ on-demand drug release remains a challenge. Here, a novel near-infrared (NIR) laser-induced blasting carrier-free nanodrug delivery system is designed and fabricated by coating doxorubicin (DOX) nanoparticles (DNPs) with a polydopamine film (PDA) that would prolong the blood circulation time of DNPs and avoid the preleakage of the DOX during blood circulation. Meanwhile, the NH4HCO3 is introduced to trigger in situ "bomb-like" release of DOX for the production of carbon dioxide (CO2) and ammonia (NH3) gases driven by NIR irradiated photothermal effect of PDA. Both in vitro and in vivo studies demonstrate that the carrier-free nanovectors with high drug loading efficiency (85.8%) prolong tumor accumulation, enhance chemotherapy, achieve the synergistic treatment of chemotherapy and photothermal treatment, and do not induce any foreign-body reaction over a three-week implantation. Hence, the delicate design opens a self-assembly path to develop PDA-based NIR-responsive multifunctional carrier-free nanoparticles for tumor therapy.

References

Oct 20, 2007·Science·Haeshin LeePhillip B Messersmith
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Aug 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meng YuNan Li
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hong-Jun LiJun Wang
Jan 27, 2017·ACS Applied Materials & Interfaces·Yi YiWeihong Tan
Mar 16, 2017·International Journal of Nanomedicine·Jizhu XiaZhigang Wang
Aug 24, 2017·Advanced Materials·Martin AntensteinerMohammad Reza Abidian

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Citations

Mar 7, 2019·Biomaterials Science·Rushikesh S Ambekar, Balasubramanian Kandasubramanian
Oct 17, 2019·Chemical Communications : Chem Comm·Yang LiMaling Gou
Feb 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhongxiong FanZhenqing Hou
Nov 7, 2019·Frontiers in Bioengineering and Biotechnology·Zuhong LiLanjuan Li
Aug 21, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jinfeng LiaoZhiyong Qian
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Long ZhangXingjie Zan
Feb 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Juanrong QinBotao Song
Jul 16, 2020·Physical Chemistry Chemical Physics : PCCP·Juan Sebastian PappalardoRafik Naccache
Oct 29, 2020·Chemical Society Reviews·Jiajie ChenJianlin Shi
Aug 24, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Fei YinJianxun Ding
Sep 30, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Gladys A EmechebeCheol Sang Kim
Feb 18, 2021·Chemical Society Reviews·Di WuJesse V Jokerst
Feb 26, 2021·International Journal of Nanomedicine·Zehra EdisMunazza Ijaz
May 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haotian LuAiguo Hu
Jun 9, 2021·Chemical Society Reviews·Peng YangYiwen Li
Jun 3, 2021·International Journal of Molecular Sciences·Ying SunHao Hu
May 31, 2019·Analytical Chemistry·Lei JiaoChengzhou Zhu
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
Fluorescence
fluorescence microscopy
Assay
xenograft

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