NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy

International Journal of Nanomedicine
Ruifen GeYong Sun

Abstract

Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is a promising noninvasive strategy in the treatment of cancers due to its highly localized specificity to tumors and minimal side effects to normal tissues. However, single phototherapy often causes tumor recurrence which hinders its clinical applications. Therefore, developing a NIR-guided dendritic nanoplatform for improving the phototherapy effect and reducing the recurrence of tumors by synergistic chemotherapy and phototherapy is essential. A fluorescent targeting ligand, insisting of ICG derivative cypate and a tumor penetration peptide iRGD (CRGDKGPDC), was covalently combined with PAMAM dendrimer to prepare a single agent-based dendritic theranostic nanoplatform iRGD-cypate-PAMAM-DTX (RCPD). Compared with free cypate, the resulted RCPD could generate enhanced singlet oxygen species while maintaining its fluorescence intensity and heat generation ability when subjected to NIR irradiation. Furthermore, our in vitro and in vivo therapeutic studies demonstrated that compared with phototherapy or chemotherapy alone, the combinatorial chemo-photo treatment of RCPD with the local exposure of NIR light can significantly improve anti-tumor effici...Continue Reading

Citations

Feb 11, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Yan LiangYong Sun
Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Serge MignaniJean-Pierre Majoral
Apr 29, 2020·Drug Discovery Today·Bapi GorainPrashant Kesharwani
May 25, 2021·Materials Today. Bio·Zhijun OuyangXiangyang Shi

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Methods Mentioned

BETA
confocal microscopy
confocal
flow cytometry
Fluorescence
irradiate

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