NIR nanoprobe-facilitated cross-referencing manifestation of local disease biology for dynamic therapeutic response assessment.

Chemical Science
Zhimin WangBengang Xing

Abstract

Pharmacological interventions for effective treatment require opportune, dynamic and accurate manifestation of pathological status. Traditional clinical techniques relying on biopsy-based histological examinations and blood tests are dramatically restricted due to their invasiveness, unsatisfactory precision, non-real-time reporting and risk of complications. Although current strategies through molecular imaging enable non-invasive and spatiotemporal mapping of pathological changes in intact organisms, environment-activatable, sensitive and quantitative sensing platforms, especially for dynamic feedback of the therapeutic response, are still urgently desired in practice. Herein, we innovatively integrate deep-tissue penetrable multispectral optoacoustic tomography (MSOT) and near-infrared (NIR) optical imaging based technology by tailoring a free radical-responsive chromophore with photon-upconverting nanocrystals. During the therapeutic process, the specific reactions between the drug-stimulated reactive oxygen species (ROS) and radical-sensitive probes result in an absorption shift, which can be captured by MSOT. Meanwhile, the radical-triggered reaction also induces multispectral upconversion luminescence (UCL) responses tha...Continue Reading

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Citations

May 20, 2020·Chemistry, an Asian Journal·Zhimin Wang, Bengang Xing
Mar 4, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Quanchao DuEdwin K L Yeow
Mar 17, 2021·Advanced Biology·Tiancong Ma, Tian Xia

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Methods Mentioned

BETA
biopsy
biopsies
transmission electron microscopy
imaging technique

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