NIR photo-driven upconversion in NaYF4 :Yb,Er/PLGA particles for in vitro bioimaging of cancer cells

Materials Science & Engineering. C, Materials for Biological Applications
Lidija MancicOlivera Milosevic

Abstract

Lanthanide-doped fluoride up-converting nanoparticles (UCNPs) represent the new class of imaging contrast agents which hold great potential for overcoming existing problems associated with traditionally used dyes, proteins and quantum dots. In this study, a new kind of hybrid NaYF4:Yb,Er/PLGA nanoparticles for efficient biolabeling were prepared through one-pot solvothermal synthesis route. Morphological and structural characteristics of the as-designed particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive spectroscopy (EDS), Fourier transform infrared (FTIR) and photoluminescence (PL) spectroscopy, while their cytotoxicity as well as up-conversion (UC) labeling capability were tested in vitro toward human gingival cells (HGC) and oral squamous cell carcinoma (OSCC). The results revealed coexistence of the cubic (Fm-3m) and hexagonal (P63/m) phase in spherical and irregularly shaped nanoparticles, respectively. PLGA [Poly(lactic-co-glycolic acid)] ligands attached at the surface of UCNPs particles provide their enhanced cellular uptake and enable high-quality cells imaging through a near-infrared (NIR) laser scanning microscopy (λex = 980 nm). M...Continue Reading

Citations

Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Danica Z ZmejkoskiBiljana M Todorović Marković
Mar 21, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Rafia RafiqueTae Jung Park

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