PMID: 18187871Jan 12, 2008Paper

NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease

Endocrine Journal
Aya GotoMorikazu Onji

Abstract

Subtotal thyroidectomy for Graves' disease sometimes leads to hypothyroidism or relapse during long-term follow-up in a significant proportion of patients. Factors predictive of postoperative hypothyroidism after subtotal thyroidectomy are not known. The objective of this study was to determine the relation between clinical features and expression of transcripts associated with thyroid hormone synthesis in resected thyroid tissues of patients with Graves' disease. Thyroid tissues were obtained from 65 patients with Graves' disease who underwent subtotal thyroidectomy. Expression of mRNAs from thyroglobulin (Tg), TSH receptor (TSHR), thyroid peroxidase (TPO), sodium/iodide symporter (NIS), and the Pendred's syndrome (PDS) genes were analyzed by quantitative reverse transcription-polymerase chain reaction. Uni- and multivariate analyses were performed to identify for postoperative hypothyroidism. We detected significant correlations between the NIS mRNA level and levels of free T(3) (fT(3)) and free T(4) (fT(4)) and between the Tg mRNA level and goiter weight before initial drug treatment. Mean levels of expression of all five mRNAs were significantly higher in patients who did not require L-thyroxine replacement therapy than in ...Continue Reading

References

Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·M C Brown, R Spencer
Jun 1, 1990·Acta Endocrinologica·B WinsaF A Karlsson
Jun 15, 1987·European Journal of Biochemistry·Y Malthiéry, S Lissitzky
Feb 1, 1996·Clinical Nuclear Medicine·U S VemulakondaH A Ziessman
Feb 1, 1997·Journal of Medical Genetics·E GausdenR Trembath
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·O LevyN Carrasco
Jun 1, 1997·Thyroid : Official Journal of the American Thyroid Association·P VittiA Pinchera
Mar 24, 1998·Thyroid : Official Journal of the American Thyroid Association·V MichelangeliP Colman
Jun 9, 1998·Human Molecular Genetics·B CoyleR C Trembath
Jul 14, 1998·The Journal of Clinical Endocrinology and Metabolism·F ArturiS Filetti
Sep 16, 1999·The Journal of Clinical Endocrinology and Metabolism·V LazarM Schlumberger
Apr 25, 2000·Thyroid : Official Journal of the American Thyroid Association·H J ParkI M Ahn
Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·J SeisslerN G Morgenthaler
Sep 29, 2001·Thyroid : Official Journal of the American Thyroid Association·C MianB Caillou
Nov 1, 2003·Thyroid : Official Journal of the American Thyroid Association·Anne DenizotL'Houcine Ouafik
Sep 15, 2004·European Journal of Endocrinology·Markus EszlingerRalf Paschke
Jul 25, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Pamela L StrisselReiner Strick

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Citations

Apr 12, 2014·International Journal of Endocrinology·Anna Popławska-KitaMaria Górska

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