Nitinol Stents in the Femoropopliteal Artery: A Mechanical Perspective on Material, Design, and Performance

Annals of Biomedical Engineering
Kaspars MaleckisAlexey Kamenskiy

Abstract

Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement. Restenosis and progression of native arterial disease often lead to recurrence of symptoms and reinterventions that increase morbidity and health care expenditures. One of the main factors thought to be associated with stent failure in the femoropopliteal artery (FPA) is the unique and highly dynamic mechanical environment of the lower limb. Clinical and experimental data demonstrate that the FPA undergoes significant deformations with limb flexion. It is hypothesized that the inability of many existing stent designs to conform to these deformations likely plays a role in reconstruction failure, as repetitive movements of the leg and thigh combin...Continue Reading

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Citations

May 7, 2020·Acta chirurgica Belgica·Jasper CornetteC P Lange
Dec 3, 2020·Pharmaceuticals·Claire V CawthonSaami K Yazdani
Jan 29, 2021·Cardiovascular and Interventional Radiology·Christopher J GrilliAssaf Graif
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Jun 29, 2021·Experimental and Therapeutic Medicine·Mircea Catalin CosarcaVasile Adrian Mureșan
Jan 13, 2022·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Giorgio A MedrandaNelson L Bernardo

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Methods Mentioned

BETA
amputation
surgical bypass
X-ray
SMA
SMAs
Differential Scanning Calorimetry

Software Mentioned

Smart Flex
Supera
ABAQUS
ANSYS
Absolute Pro
LifeStent
FlexStar
VUMAT
Smart
Protégé GPS

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