Nitrate: An Environmental Endocrine Disruptor? A Review of Evidence and Research Needs

Environmental Science & Technology
Rikke PoulsenMartin Hansen

Abstract

Nitrate is heavily used as an agricultural fertilizer and is today a ubiquitous environmental pollutant. Environmental endocrine effects caused by nitrate have received increasing attention over the last 15 years. Nitrate is hypothesized to interfere with thyroid and steroid hormone homeostasis and developmental and reproductive end points. The current review focuses on aquatic ecotoxicology with emphasis on field and laboratory controlled in vitro and in vivo studies. Furthermore, nitrate is just one of several forms of nitrogen that is present in the environment and many of these are quickly interconvertible. Therefore, the focus is additionally confined to the oxidized nitrogen species (nitrate, nitrite and nitric oxide). We reviewed 26 environmental toxicology studies and our main findings are (1) nitrate has endocrine disrupting properties and hypotheses for mechanisms exist, which warrants for further investigations; (2) there are issues determining actual nitrate-speciation and abundance is not quantified in a number of studies, making links to speciation-specific effects difficult; and (3) more advanced analytical chemistry methodologies are needed both for exposure assessment and in the determination of endocrine bioma...Continue Reading

References

Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·E LahtiO V Lindqvist
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·O G KhatsenkoJ R Vane
Jan 1, 1995·Biology of Reproduction·A L BurnettT S Chang
Aug 1, 1995·Nature Medicine·J L ZweierP Kuppusamy
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J StadlerJ Doehmer
Jan 1, 1993·Annual Review of Biochemistry·A KolbS Adhya
Jan 1, 1993·Archives of Biochemistry and Biophysics·D A WinkR W Nims
Nov 18, 1996·The Science of the Total Environment·P D Hebert, M M Luiker
Dec 1, 1996·Endocrinology·K Del PuntaO P Pignataro
Apr 1, 1997·Molecular Human Reproduction·M MasudaT Aso
Aug 26, 1998·General and Comparative Endocrinology·A De Loof, R Huybrechts
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·B A CookeM Choi
Nov 14, 2000·Archives of General Psychiatry·C M Meston, P F Frohlich
Jan 3, 2001·Toxicology and Applied Pharmacology·N S Panesar, K W Chan
Feb 13, 2001·Trends in Cell Biology·C Bogdan
Apr 3, 2001·The Journal of Steroid Biochemistry and Molecular Biology·T S KosticR Z Kovacevic
Jul 18, 2001·The Journal of Steroid Biochemistry and Molecular Biology·E OberdörsterM J Milner
Mar 28, 2002·Physiological Reviews·Thomas J JentschAnselm A Zdebik
Sep 21, 2002·Molecular and Cellular Endocrinology·James G DrewettDavid J Hegge
Sep 25, 2002·General and Comparative Endocrinology·Serge Van der GeytenVeerle M Darras
Nov 1, 2002·Nature·Tyrone HayesAaron Vonk
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Ralf Lösel, Martin Wehling
May 3, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Frank B Jensen
Oct 31, 2003·Nature·Nicola Nosengo
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Yukiko MinamiyamaShigeru Okada
Nov 6, 2003·Insect Biochemistry and Molecular Biology·Luc Swevers, Kostas Iatrou
Mar 31, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Edward J ScollonGeorge P Cobb
Oct 2, 2004·Science·Anthony D BarnoskyAlan B Shabel
Jan 26, 2005·Chemosphere·Julio A CamargoAnnabella Salamanca
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hermes J GarbánLouis J Ignarro
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Aug 13, 2005·Clinical and Experimental Medicine·S EskiocakS Altaner
Nov 29, 2005·Frontiers in Neuroendocrinology·Cheryl L Sisk, Julia L Zehr
Feb 10, 2006·International Journal of Andrology·Thea M EdwardsLouis J Guillette
Feb 24, 2006·Environmental Toxicology and Chemistry·Frances OrtonRichard D Handy
Mar 30, 2006·Aquatic Toxicology·Thea M EdwardsLouis J Guillette
May 17, 2006·Trends in Ecology & Evolution·L Michael Romero

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Citations

Oct 24, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Hina RashidSaeed Alshahrani
Feb 3, 2020·Archives of Environmental Contamination and Toxicology·Adrian P Moore, Robert B Bringolf
Mar 25, 2020·International Journal of Environmental Research and Public Health·Luke R IwanowiczJohn Abatemarco
May 26, 2020·Molecular and Cellular Endocrinology·Vance L TrudeauValérie S Langlois
Nov 1, 2018·The Science of the Total Environment·Ningxin ChenPierre Ribstein
Jul 16, 2021·Ecotoxicology and Environmental Safety·Bixia LiBoguang Wang
Jan 4, 2022·Environmental Science & Technology·Larry B BarberAlan M Vajda

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