PMID: 7029267Sep 1, 1981Paper

Nitrated fluorene derivatives are potent frameshift mutagens

Mutation Research
E C McCoyR Mermelstein

Abstract

Nitrated derivatives if fluorene are potent frameshift-type mutagens. A reduction of the nitro function is required for the expression of mutagenicity. Hydroxylamines are the presumed key intermediates, which following esterification to electrophiles are capable of forming adducts with cellular DNA. Evidence in support of this mechanism is obtained by the use of tester strains having a functional uvrB gene product or lacking specific nitroreductases. The mutagenic potency of nitrated fluorenes increases upon successive addition of nitro groups reaching a peak at the trisubstituted state. Addition of a 4th nitro group leads to decreased activity.

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Citations

Apr 24, 2013·Environmental Science and Pollution Research International·Tilman FloehrHenner Hollert
May 1, 1984·Mutation Research·G Klopman, H S Rosenkranz
Feb 1, 1993·Mutation Research·R BecherJ A Holme
Sep 1, 1988·Mutation Research·B Beije, L Möller
Feb 1, 1983·Mutation Research·E C McCoyR Mermelstein
Aug 1, 1983·Mutation Research·W G SorensonT Ong
Aug 1, 1985·Mutation Research·T SatoT Ishikawa
Apr 1, 1982·Mutation Research·W T SpeckH S Rosenkranz
Apr 1, 1983·Journal of Toxicology and Environmental Health·R L HansonD F Hunt
Jan 1, 1983·Drug and Chemical Toxicology·W E White, S G Rock
Jan 1, 1982·Cancer Letters·E C McCoy, H S Rosenkranz
Dec 1, 1986·Biomedical & Environmental Mass Spectrometry·L Möller, J A Gustafsson
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Jan 1, 1991·Environmental and Molecular Mutagenesis·V Mersch-SundermannF Wintermann
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Jan 1, 1986·Teratogenesis, Carcinogenesis, and Mutagenesis·P HreliaG Cantelli-Forti
Mar 19, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Osamu UedaShigeru Ohta

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