Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats.

Molecular Psychiatry
Seva G KhambadkoneRobert H Yolken

Abstract

Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24-5.45, p < 8.97 × 10-8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to rats resulted in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated in human bipolar disorder, and changes in intestinal microbiota. These findings may lead to new methods for preventing mania and for developing novel therapeutic interventions.

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Citations

Sep 19, 2018·Nutrients·Klaudia Modlinska, Wojciech Pisula
Mar 9, 2019·Molecular Psychiatry·Conrad M Swartz
Dec 11, 2020·Animals : an Open Access Journal From MDPI·Marzena ZającMałgorzata Tabaszewska
Jan 30, 2021·Bipolar Disorders·M Elizabeth SubletteJeffrey M Miller

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Methods Mentioned

BETA
in vitro transcription
Illumina sequencing

Software Mentioned

STATA
Statistica

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