Nitrated polycyclic aromatic hydrocarbons: potent bacterial mutagens and stimulators of DNA repair synthesis in cultured human cells

Carcinogenesis
J CampbellA Rutter

Abstract

Ten polycyclic aromatic hydrocarbons (PAHs), viz. anthracene pyrene, chrysene, perylene, fluoranthene, benzo[a]pyrene, benzo[a]pyrene, benz[a]anthracene, benzo[ghi]perylene, benzo[k]fluoranthene, have been nitrated using concentrated nitric acid and the crude nitrated mixture examined for biological activity. All the nitro PAHs examined were mutagenic to Salmonella typhimurium in the absence of a rat liver preparation. Addition of Aroclor-1254 induced liver had little effect on mutagenicity. Mutagenic potency differed for the various nitrated mixtures with nitrated pyrene and nitrated fluoranthene the most potent and nitrated anthracene the least potent. Both frame-shift and base-substitution mutations were induced by the nitrated PAHs. The nitrated PAHs were also able to induce DNA repair synthesis in cultured HeLa cells in the absence of liver, indicating that these cells have the necessary enzymes to activate nitro PAHs. Potency again varied from compound to compound with nitrated pyrene appearing to be the most active. Isolation of individual components from the crude nitrated mixtures has not been carried out in this study. In view of the possible wide-spread distribution of nitrated PAHs in the environment further work is...Continue Reading

Citations

Jan 1, 1991·Archives of Microbiology·M A HeitkampC E Cerniglia
Mar 1, 1982·Mutation Research·H S Rosenkranz
Dec 1, 1990·Mutation Research·P P FuR H Heflich
May 1, 1987·Mutation Research·M E Lambert, I B Weinstein
Jan 1, 1991·Toxicology Letters·Y UnoM Morita
Feb 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K KangsadalampaiK Manoonphol
Apr 1, 1983·Journal of Toxicology and Environmental Health·R L HansonD F Hunt
Jan 1, 1986·Journal of Toxicology and Environmental Health·B W ManningT W Federle
Jan 1, 1986·Journal of Toxicology and Environmental Health·G C MillnerC E Cerniglia
Dec 1, 1986·Environmental Health Perspectives·G MatanoskiL Wallace
Jan 1, 1990·Drug Metabolism Reviews·P P Fu
Aug 30, 1984·Biochemical and Biophysical Research Communications·C E CernigliaW Franklin
Feb 1, 1986·Toxicology and Applied Pharmacology·L C KingJ Lewtas
Jan 1, 1982·Cancer Letters·E C McCoy, H S Rosenkranz
Apr 1, 1984·Cancer Letters·L C KingJ Lewtas
Oct 1, 1985·Environmental Health Perspectives·M A JacksonJ Lewtas
Jan 1, 1995·Critical Reviews in Toxicology·A R GoeptarN P Vermeulen
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Sep 1, 1985·Applied and Environmental Microbiology·C E CernigliaD W Miller
Jan 1, 1988·Applied and Environmental Microbiology·B W ManningC E Cerniglia
Sep 15, 1983·Chemico-biological Interactions·R ToftgårdJ A Gustafsson

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