PMID: 799990Jan 1, 1976

Nitrazepam and temazepam: a comparative trial of two hypnotics

The Journal of International Medical Research
R G Priest, Z A Rizvi


A specially designed sleep questionnaire was used to assess the performance of the two hypnotic drugs. Psychiatric patients were given 5 mg nitrazepam or 10 mg temazepam in identical capsules, and were allowed more if necessary. A double-blind cross-over design was used. We found that 5-2 mg nitrazepam showed few differences from 13-2 mg temezepam. The two regimes produced fairly similar reports on patient satisfaction, quality of sleep, number of awakenings, depth of sleep and other variables. Patients on nitrazepam were a little more clear-headed in the morning, though they tended to wake later, sleep longer, and take more sleep over the 24-hour period. No toxicity was found with either drug over the 434 patient days of administration. In view of the advantages of the benzodiazepine drugs over their predecessors, we feel that it is worth exploring further the use of temazepam as a sleep inducing drug.


May 1, 1973·The Journal of Pharmacy and Pharmacology·G T Hajos, S Garattini
Aug 22, 1973·Psychopharmacologia·S R Allen, I Oswald
Oct 1, 1970·European Journal of Pharmacology·B Silvestrini, E Quadri
Aug 1, 1973·European Journal of Pharmacology·A BizziS Garattini
Feb 20, 1961·Psychopharmacologia·L E HOLLISTERR O DEGAN
Nov 6, 1965·British Medical Journal·I Oswald, R G Priest


Jan 1, 1982·Current Medical Research and Opinion·D Van Steenis
Sep 1, 1983·British Journal of Clinical Pharmacology·I C McManusR G Priest
Apr 27, 2002·Journal of Clinical Pharmacy and Therapeutics·M Ramesh, G Roberts
Mar 25, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Matteo GiordaniLaura Valentini
Jul 1, 1981·Pharmacotherapy·M M Mitler
Jan 1, 1979·The Journal of International Medical Research·C A Moon, M Schiller
Sep 1, 1982·Drug Intelligence & Clinical Pharmacy·J C McElnayB Alexander

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