Nitric oxide, a potent vasodilator of the aortic anastomosis in the estuarine crocodile, Crocodylus porosus

General and Comparative Endocrinology
M AxelssonC E Franklin

Abstract

The effects of five neuropeptides (CGRP, SOM, SP, NPY, VIP), L-NAME (nitric oxide synthase inhibitor), and adrenaline on the contractile tone of the aortic anastomosis in the estuarine crocodile, Crocodylus porosus, were investigated. None of the neuropeptides, which had previously been found to be present in the aortic anastomosis, had any direct effect on the tension developed by ring preparations. L-NAME itself significantly increased the basal tone of the vascular ring preparations, suggesting a tonic release of nitric oxide in the preparation. Adrenaline produced concentration-dependent vasoconstrictions that were counteracted by profound reflex vasodilatations that were susceptible to blockade by L-NAME. Immunohistochemistry revealed the presence of nitric oxide synthase and tyrosine hydroxylase-containing (indicating the presence of a adrenergic innervation) nerve fibres in the adventitia and adventitio-medial border of the aortic anastomosis. These data demonstrate opposing actions of adrenaline and nitric oxide on the vascular smooth muscle in the anastomosis of the C. porosus. The morphology of the anastomosis, with the extremely thick muscular vessel wall, suggests a sphincter-like function for this vessel that could...Continue Reading

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Citations

Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John A DonaldMelissa S Cameron
Feb 24, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Gina L J GalliTobias Wang
Jun 4, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Michael Axelsson, Craig E Franklin
Nov 3, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mark MerchantKaili Mills
Oct 6, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Bjarke JensenDane A Crossley
Nov 8, 2001·Experimental Physiology·M Axelsson
Sep 6, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John A Donald, Brad R S Broughton
Jun 29, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nini SkovgaardTobias Wang
Oct 24, 2014·Pflügers Archiv : European journal of physiology·Noboru Toda, Tomio Okamura
Jul 19, 2011·Respiratory Physiology & Neurobiology·Manuela N GardnerDavid R Jones
Dec 21, 2019·Biological Reviews of the Cambridge Philosophical Society·Warren BurggrenTobias Wang
Dec 16, 2006·The Journal of Experimental Biology·Brad R S Broughton, John A Donald

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