Nitric Oxide-Activated "Dual-Key-One-Lock" Nanoprobe for in Vivo Molecular Imaging and High-Specificity Cancer Therapy

Journal of the American Chemical Society
Lili TengWeihong Tan

Abstract

Cancer treatments are confounded by severe toxic effects toward patients. To address these issues, activatable nanoprobes have been designed for specific imaging and destruction of cancer cells under the stimulation of specific cancer-associated biomarkers. Most activatable nanoprobes were usually activated by some single-factor stimulation, but this restricts therapeutic specificity between diseased and normal tissue; therefore, multifactor activation is highly desired. To this end, we herein develop a novel dual-stimuli responsive theranostic nanoprobe for simultaneously activatable cancer imaging and photothermal therapy under the coactivation of "dual-key" stimulation of "nitric oxide (NO)/acidity", so as to further improve the therapeutic specificity. Specifically, we have integrated a weak electron acceptor (benzo[c][1,2,5]thiadiazole-5,6-diamine) into a donor-π-acceptor-π-donor type chromophore. When the weak acceptor was oxidized by NO in acidic conditions to form a stronger acceptor (5H-[1,2,3]triazolo[4,5-f]-2,1,3-benzothiadiazole), the molecule absorption was significantly increased in the near-infrared region, based on the intramolecular charge transfer (ICT) mechanism. Under the dual-key stimulation of NO/acidity w...Continue Reading

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Citations

Dec 19, 2019·Chemical Communications : Chem Comm·Yijing DangWen Zhang
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Lingling LiWen Zhang
Sep 6, 2020·International Journal of Molecular Sciences·Gengqi LiuYumiao Zhang
Nov 4, 2020·Chemistry : a European Journal·Francis L BuguisJoe B Gilroy
Mar 17, 2021·Advanced Biology·Tiancong Ma, Tian Xia
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qiang ZhangFeng Gao
May 8, 2021·Journal of Colloid and Interface Science·Jinxiu XiaMin Zheng
Jun 12, 2021·Chemical Communications : Chem Comm·Fanpeng KongBo Tang
May 6, 2021·ChemMedChem·Li XuGuosheng Song
Jun 18, 2021·Chemical Communications : Chem Comm·Kaiye WangBo Tang
Jun 25, 2021·Chemical Science·Amanda K EastJefferson Chan
Jun 10, 2020·ACS Applied Materials & Interfaces·Yite LiZhigang Xie
Dec 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaxi LiKai Li

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