PMID: 9183484May 1, 1997Paper

Nitric oxide and aneurysm formation in Kawasaki disease

Acta Paediatrica
T IizukaM Koike

Abstract

The objective of this study is to show that nitric oxide plays a role in the development of coronary artery abnormalities in Kawasaki disease. We examined nitrite+nitrate, biopterin and neopterin in 316 urine samples of 34 patients with Kawasaki disease, those of 24 patients with other diseases, and those of 25 healthy children acting as a control group, because urinary nitrite + nitrate are reportedly useful as markers of nitric oxide generation in vivo, and pathways for neopterin-biopterin synthesis and nitric oxide generation are tightly coupled. In our study, the children with Kawasaki disease excreted more urinary nitrite + nitrate and neopterin than did the healthy control group children and excreted abnormally high quantities more often than did the patients with other diseases. Good relationships were found between the urinary nitrite + nitrate levels and the urinary biopterin levels, and between these biopterin levels and the urinary neopterin levels. Nitric oxide is therefore thought to be generated in abnormally high quantities, and to be closely related to the pathology of Kawasaki disease and to the development of coronary artery abnormalities. The role of nitric oxide in Kawasaki disease should be further studied ...Continue Reading

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Citations

Jul 1, 1998·Clinical Biochemistry·G EllisS K Makela
Jan 15, 1998·The Journal of Pediatrics·T IizukaY Minatogawa
Jul 26, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Jolanta M DzikElzbieta Walajtys-Rode
Apr 22, 1999·Archives of Disease in Childhood·J TakayaY Kobayashi
Apr 22, 2003·The Tohoku Journal of Experimental Medicine·Figen NarinDuran Aslan
Aug 13, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Yumiko IkemotoYohnosuke Kobayashi
Apr 24, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Vahid KhajoeeToshiro Hara
Jan 24, 2006·Journal of Vascular Research·Michèle CoutardJean-Baptiste Michel
Feb 10, 2016·PloS One·Zhen LiUNKNOWN Emergency Medicine Kawasaki Disease Research Group
Aug 5, 2000·Alaska Medicine·K W Moss
Apr 4, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·H SuzukiM Koike
Oct 8, 1999·Vascular Medicine·J W Newburger, J C Burns

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