Nitric oxide and arterial disease

Journal of Vascular Surgery
Joel E Barbato, Edith Tzeng

Abstract

Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of vascular disease. NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been intensively investigated and further elucidated over the past two decades. It is important in the pathogenesis of many cardiovascular diseases, including atherosclerosis, intimal hyperplasia, and aneurysmal disease. In addition, NO has been used as a therapeutic tool to treat diseases that range from recurrent stenosis to inhibiting thrombotic events. Many commonly used medications have their therapeutic actions through the production of NO. This review highlights the vascular biologic characteristics of NO, its role in the pathogenesis of cardiovascular disease processes, and its potential therapeutic applications.

References

Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·C NapoliL J Ignarro
Apr 30, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kai WangA Michael Lincoff

❮ Previous
Next ❯

Citations

Sep 26, 2008·The Journal of Biological Chemistry·Jesús TejeroDennis J Stuehr
Apr 8, 2010·Annual Review of Biochemistry·Brian R CraneBhumit A Patel
Nov 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Anjali S GodboleGhassan S Kassab
Jan 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jeff S IsenbergWilliam A Frazier
Sep 30, 2010·Biomedical Engineering Online·Luis A BritoMansoor M Amiji
Sep 24, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Jörg MuntwylerMartin Hersberger
Sep 7, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Farrah J Mateen, Ashfaq Shuaib
Mar 19, 2015·Biomolecules·Kerstin NowotnyTilman Grune
Dec 17, 2014·Clinical and Experimental Hypertension : CHE·Wei XiaYingjie Yao
May 31, 2008·FEBS Letters·Patricia GangoitiAntonio Gómez-Muñoz
Sep 5, 2012·Annals of Vascular Surgery·Nan ZhangChunli Cao
Jul 20, 2010·Annals of Vascular Surgery·Francisco MedinaFrancisco Acin
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·J Kucinska-LipkaM Sienkiewicz
Apr 17, 2012·Nitric Oxide : Biology and Chemistry·Matthew J AlefBrian S Zuckerbraun
May 11, 2007·Vascular Pharmacology·Boris YoffeAbraham Baruchin
Sep 21, 2005·Journal of Vascular Surgery·Cinzia FatiniGiovanni Pratesi
May 23, 2006·British Journal of Pharmacology·Karina KrotovaSergey Zharikov
Jun 30, 2010·Molecular Reproduction and Development·Mohammad Reza SafarinejadSaba Safarinejad
Dec 5, 2006·Journal of Ethnopharmacology·Ana Paula S AzevedoFlávia R F Nascimento
Jan 4, 2006·Atherosclerosis·J M DijkUNKNOWN SMART-Study Group
May 19, 2010·Journal of Vascular Surgery·Elena SticchiCinzia Fatini
Jun 26, 2014·International Journal of Vascular Medicine·Andrew W GardnerWilliam E Sonntag
Jul 21, 2012·Trends in Cardiovascular Medicine·Bilal AtayaBrian S Zuckerbraun
Feb 13, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E Martínez AguilarF Acín García
Jul 11, 2006·Journal of Vascular Surgery·Kathleen G RamanEdith Tzeng
Jul 6, 2016·Diabetes & Metabolic Syndrome·Sandra Maria BarbalhoMarie Oshiiwa
Apr 12, 2006·International Heart Journal·Takayuki OhwadaYukio Maruyama
Oct 31, 2007·Journal of Materials Science. Materials in Medicine·Erdem ArslanLevent Trabzon
Dec 5, 2008·Angiology·Francisco José Medina MaldonadoFrancisco Acín García
Jul 15, 2015·Journal of Cardiovascular Pharmacology·Ning GuoYong Zhang
Sep 22, 2019·Journal of Clinical Medicine·Ahmed IsmaeelPanagiotis Koutakis
May 25, 2005·European Heart Journal·Arnold G Herman, Salvador Moncada
Feb 9, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Walter B CicariniMaria G Carvalho
Nov 9, 2012·Journal of Endocrinological Investigation·W XiaY Chi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.